SNCAIP antibody

Catalog No. ABIN285957

Product Details anti-SNCAIP Antibody

Target: SNCAIP (Synuclein, alpha Interacting Protein (SNCAIP))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This SNCAIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: Synphilin 1 antibody was raised in goat using a peptide, SLELNGEKDKDKGRTLQRT, as the immunogen.

Application Details

Application Notes: ELISA: >1:10,655, IHC-P: >1:400, WB: >1:2,000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as liquid whole serum without preservative

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details for SNCAIP

Target: SNCAIP (Synuclein, alpha Interacting Protein (SNCAIP))

Alternative Name: Synphilin 1 (SNCAIP Products)

Synonyms: sncaip antibody, MGC88953 antibody, SNCAIP antibody, LOC100221074 antibody, SYPH1 antibody, Sph1 antibody, Syph1 antibody, 2810407O15Rik antibody, 4933427B05Rik antibody, BB104594 antibody, synuclein alpha interacting protein antibody, synuclein, alpha interacting protein antibody, synuclein, alpha interacting protein (synphilin) antibody, SNCAIP antibody, sncaip antibody, Sncaip antibody

Background: Synphilin-1 is a cytoplasmic protein that is enriched in the neurophil of normal human brain. Although the exact function of synphilin-1 is unknown, it may possibly have a role as a cytoskeletal protein based on the presence of ankyrin-like repeats and an ATP, GTP-binding domain. It has been shown to be novel is its ability to associate in vivo with a-synuclein to form cytoplasmic eosinophilic inclusions. Additionally, it has been observed to be present in Lewy bodies of Parkinson disease, which are composed of a-synuclein. Because synphilin-1 is not found in protein aggregates of Alzheimer’s disease, it appears to be specific for a-synuclein-containing lesions. Synphilin-1 may facilitate the aggregation of a-synuclein into Lewy bodies.