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GAP43 antibody (Growth Associated Protein 43) (AA 216-238) Primary Antibody

GAP43 Reactivity: Human, Mouse, Rat IHC (p), WB Host: Rabbit Polyclonal unconjugated
Pubmed (10)
Catalog No. ABIN3043685
$315.00
Plus shipping costs $45.00
100 μg
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  • Target See all GAP43 Antibodies
    GAP43
    Binding Specificity
    • 30
    • 16
    • 10
    • 10
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 216-238, C-Term
    Reactivity
    • 113
    • 113
    • 106
    • 21
    • 12
    • 12
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 100
    • 23
    • 7
    • 2
    • 1
    Rabbit
    Clonality
    • 104
    • 29
    Polyclonal
    Conjugate
    • 84
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GAP43 antibody is un-conjugated
    Application
    • 72
    • 41
    • 27
    • 26
    • 26
    • 23
    • 23
    • 22
    • 20
    • 18
    • 17
    • 4
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Neuromodulin(GAP43) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequence
    KPKESARQDE GKEEEPEADQ EHA
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Neuromodulin(GAP43) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: growth associated protein 43
    Protein Name: Neuromodulin
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human GAP43(216-238aa KPKESARQDEGKEEEPEADQEHA), different from the related mouse and rat sequences by one amino acid.
    Isotype
    IgG
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Liu, Lv, Zhu, Wu, Zhang, Xu, Zheng, Zhao: "Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo." in: Scientific reports, Vol. 7, pp. 39869, 2018 (PubMed).

    Tan, Yu, Song, Zou, Xu, Liu: "Expression of MicroRNA-29a Regulated by Yes-Associated Protein Modulates the Neurite Outgrowth in N2a Cells." in: BioMed research international, Vol. 2017, pp. 5251236, 2018 (PubMed).

    Liu, Liu, Zeng et al.: "Chronic Unpredictable Mild Stress Causing Cardiac and Thoracic Spinal Cord Electrophysiological Abnormalities May Be Associated with Increased Cardiac Expression of Serotonin and Growth-Associated ..." in: BioMed research international, Vol. 2018, pp. 8697913, 2018 (PubMed).

    Yuan, Sun, Yu, An: "Human microvascular endothelial cell promotes the development of dorsal root ganglion neurons via BDNF pathway in a co-culture system." in: Bioscience, biotechnology, and biochemistry, Vol. 81, Issue 7, pp. 1335-1342, 2017 (PubMed).

    Zhu, Liu, Wang, Nie, He, Zhang, Liu, Su: "Lentiviral-mediated growth-associated protein-43 modification of bone marrow mesenchymal stem cells improves traumatic optic neuropathy in rats." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 5691-700, 2016 (PubMed).

    Zou, Ding, Shi, Xu, Gong, Zhang, Liu: "MicroRNA-29c/PTEN pathway is involved in mice brain development and modulates neurite outgrowth in PC12 cells." in: Cellular and molecular neurobiology, Vol. 35, Issue 3, pp. 313-22, 2015 (PubMed).

    Zou, Ding, Wang, Xiong, Peng, Du, Zhang, Liu, Gong: "MicroRNA-29A/PTEN pathway modulates neurite outgrowth in PC12 cells." in: Neuroscience, Vol. 291, pp. 289-300, 2015 (PubMed).

    Wang, Liu, Jin, Xu, Wang, Han, Yin: "Fructus Corni extract-induced neuritogenesis in PC12 cells is associated with the suppression of stromal interaction molecule 1 expression and inhibition of Ca2+ influx." in: Experimental and therapeutic medicine, Vol. 9, Issue 5, pp. 1773-1779, 2015 (PubMed).

    Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: "?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice." in: Brain research, Vol. 1552, pp. 41-54, 2014 (PubMed).

    Nie, Deng, Yang, Liu, Zhang, Wen: "Axonal regeneration and remyelination evaluation of chitosan/gelatin-based nerve guide combined with transforming growth factor-?1 and Schwann cells." in: Cell biochemistry and biophysics, Vol. 68, Issue 1, pp. 163-72, 2014 (PubMed).

  • Target
    GAP43
    Alternative Name
    GAP43 (GAP43 Products)
    Synonyms
    B-50, PP46, Basp2, GAP-43, b-50, gap-43, gap43b, pp46, cb310, gap, gap43, gap43a, growth associated protein 43, growth associated protein 43 L homeolog, growth associated protein 43 S homeolog, GAP43, Gap43, gap43.L, gap43, gap43.S
    Background
    Growth Associated Protein-43(GAP-43), also known as nerve growth-related growth peptide GAP43, shares a high degree of homology between the sequence of the human gene and the rat gene. GAP-43 is considered a crucial component of an effective regenerative response in the nervous system. Somatic cell hybrids demonstrate localization of the GAP-43 gene to human chromosome 3 and to mouse chromosome 16. GAP-43 has been termed a "growth" or "plasticity" protein because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. GAP-43 regulates growth of axons and modulates the formation of new connections.

    Synonyms: Axonal membrane protein GAP 43 antibody|Axonal membrane protein GAP-43 antibody|B 50 antibody|Calmodulin binding protein P 57 antibody|F1 antibody|GAP 43 antibody|GAP43 antibody|Growth Associated Protein 43 antibody|Growth-associated protein 43 antibody|Nerve Growth Related Peptide antibody|Nerve growth related peptide GAP43 antibody|NEUM_HUMAN antibody|Neural phosphoprotein B 50 antibody|Neural phosphoprotein B-50 antibody|Neuromodulin antibody|Neuron growth associated protein 43 antibody|pp46 antibody|Protein F1 antibody|QtrA-11580 antibody|QtrA-13071 antibody
    UniProt
    P17677
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