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TDP2 antibody

TDP2 Reactivity: Human IF, FACS, IHC (p) Host: Mouse Monoclonal TDP2-1258 unconjugated
Catalog No. ABIN4949896
  • Target See all TDP2 Antibodies
    TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
    Reactivity
    • 48
    • 30
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 47
    • 16
    Mouse
    Clonality
    • 49
    • 14
    Monoclonal
    Conjugate
    • 28
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TDP2 antibody is un-conjugated
    Application
    • 48
    • 26
    • 25
    • 21
    • 21
    • 13
    • 13
    • 11
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Protein G affinity chromatography
    Immunogen
    Human recombinant full length protein was used as the immunogen for this TDP2 antibody.
    Clone
    TDP2-1258
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product TDP2 Primary Antibody
  • Application Notes
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TDP2 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 0.5-1 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 min at RT
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Preservative
    Azide free
    Storage
    4 °C,-20 °C
    Storage Comment
    Store the TDP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
    Alternative Name
    TDP2 / ETS1 associated protein II (TDP2 Products)
    Background
    This mAb recognizes a protein of 41  kDa, which is identified as TDP2, or ETS1 associated protein II. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
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