p63 antibody
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- Target See all p63 (TP63) Antibodies
- p63 (TP63) (Tumor Protein P63 (TP63))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This p63 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- Purpose
- Rabbit anti-Human p63 Antibody / Tumor protein 63 [Sodium Azide Free]
- Specificity
- Nuclear
- Purification
- Recombinant partial human p53 protein was used as the immunogen for this p63 antibody.
- Immunogen
- Recombinant partial human p53 protein was used as the immunogen for this p63 antibody.
- Top Product
- Discover our top product TP63 Primary Antibody
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- Application Notes
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 minutes at RT - Restrictions
- For Research Use only
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- Buffer
- In 1X PBS, BSA free, sodium azide free
- Preservative
- Azide free
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- p63 (TP63) (Tumor Protein P63 (TP63))
- Alternative Name
- Tumor protein 63 (TP63 Products)
- Background
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Target Description: p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
Gene Symbol: TP63///KET///P63///P73H///P73L///TP73L
- Gene ID
- 8626
- UniProt
- Q9H3D4
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