Keratin 10 (KRT10) antibody

Details for Product No. ABIN6297642
Antigen
  • BCIE
  • BIE
  • CK10
  • EHK
  • K10
  • KPP
  • D130054E02Rik
  • K1C1
  • Krt-1.10
  • Krt1-10
  • Ka10
  • Ker10
  • KRT10
  • KRT25
  • KRT27
  • KRT28
  • keratin 10
  • keratin 10, type I S homeolog
  • keratin, type I cytoskeletal 25
  • KRT10
  • Krt10
  • krt10.S
  • LOC101085587
Reactivity
Human, Mouse (Murine)
396
151
95
57
48
7
6
5
3
2
2
2
2
1
1
Host
Mouse
251
147
4
Clonality
Monoclonal
Conjugate
Un-conjugated
18
11
7
7
7
6
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
203
188
184
153
98
66
42
26
24
24
14
10
10
3
2
1
Options
Purpose Mouse anti-Human/Mouse Cytokeratin 10 Antibody [Sodium Azide Free]
Immunogen Skin extract from a human psoriasis patient was used as the immunogen for this Cytokeratin 10 antibody.
Specificity Cytoplasmic
Purification Skin extract from a human psoriasis patient was used as the immunogen for this Cytokeratin 10 antibody.
Antigen
Alternative Name Keratin, type I cytoskeletal 10 (KRT10 Antibody Abstract)
Background

Target Description: This antibody recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). cytokeratin 10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of cytokeratin 10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, cytokeratin 10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), cytokeratin 10 is detected very frequently. Expression of cytokeratin 10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Gene Symbol: KRT10///KPP

Gene ID 3858
UniProt P13645
Application Notes FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.