Keratin 17 (KRT17) antibody

Details for Product No. ABIN6297731
Antigen
  • K17
  • Krt1-17
  • PC
  • PC2
  • PCHC1
  • Ka17
  • KRT17
  • krt16
  • si:dkeyp-113d7.7
  • KRT14
  • keratin 17
  • keratin 17 L homeolog
  • keratin 17, type I
  • keratin, type I cytoskeletal 17
  • Krt17
  • KRT17
  • krt17
  • krt17.L
  • LOC100737113
  • LOC102177275
Reactivity
Cow (Bovine), Goat, Human, Pig (Porcine), Rat (Rattus)
313
190
101
68
64
62
7
4
2
1
1
1
1
Host
Mouse
174
155
6
Clonality
Monoclonal
Conjugate
Un-conjugated
21
8
8
8
7
7
7
7
7
5
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
225
146
110
90
81
71
46
23
22
20
17
16
6
4
2
2
1
Options
Purpose Mouse anti-Human/Rat/Cow/Goat/Pig Cytokeratin 17 Antibody [Sodium Azide Free]
Immunogen The cytoskeletal fraction of rat colon epithelium was used as the immunogen for this Cytokeratin 17 antibody.
Specificity Cytoplasmic
Purification The cytoskeletal fraction of rat colon epithelium was used as the immunogen for this Cytokeratin 17 antibody.
Antigen
Alternative Name Keratin, type I cytoskeletal 17 (KRT17 Antibody Abstract)
Background

Target Description: Cytokeratin 17 (CK17, Keratin 17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IFP 's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to cytokeratin 17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. It is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as ""epithelial stem cell "" marker because cytokeratin 17 antibody marks basal cell differentiation. Cytokeratin 17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. Cytokeratin 17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20 % of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including cytokeratin 17 antibody. Also important is that cases of triple negative breast carcinoma with expression of keratin 17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually antibody to cytokeratin 17 and MUC1 immunoreactivity represents pancreatobiliary subtype whereas antibody to MUC2 and CDX2 positivity defines intestinal subtype.

Gene Symbol: KRT17

Gene ID 3872
UniProt Q04695
Application Notes FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.