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Target Description: CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular ""scavenger receptor cysteine-rich "" (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. It shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. CD6 antibody can be used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Gene Symbol: CD6