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BRE antibody

BRE Reactivity: Human, Mouse, Rat Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6298367
  • Target See all BRE Antibodies
    BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
    Reactivity
    • 27
    • 24
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 40
    • 2
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This BRE antibody is un-conjugated
    Application
    Please inquire
    Purpose
    Rabbit Anti-BRE Antibody,
    Top Product
    Discover our top product BRE Primary Antibody
  • Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    2-8°C (short-term), -20°C (long-term)
  • Target
    BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
    Alternative Name
    BRE (BRE Products)
    Synonyms
    brcc4 antibody, brcc45 antibody, BRE antibody, LOC100231620 antibody, BRCC4 antibody, BRCC45 antibody, 6030405P19Rik antibody, AI429776 antibody, B830038C02Rik antibody, im:7141046 antibody, zgc:110368 antibody, BRISC and BRCA1 A complex member 2 antibody, brain and reproductive organ-expressed (TNFRSF1A modulator) antibody, BRISC and BRCA1 A complex member 2 L homeolog antibody, babam2 antibody, BABAM2 antibody, Babam2 antibody, BRE antibody, babam2.L antibody
    Background

    Target Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

    Gene Symbol: BRE

    Gene ID
    9577
    UniProt
    Q9NXR7
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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