BRE antibody (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator))

Details for Product anti-BRE Antibody No. ABIN6298367
Antigen
  • brcc4
  • brcc45
  • BRE
  • LOC100231620
  • BRCC4
  • BRCC45
  • 6030405P19Rik
  • AI429776
  • B830038C02Rik
  • im:7141046
  • zgc:110368
  • BRISC and BRCA1 A complex member 2
  • brain and reproductive organ-expressed (TNFRSF1A modulator)
  • BRISC and BRCA1 A complex member 2 L homeolog
  • babam2
  • BABAM2
  • Babam2
  • BRE
  • babam2.L
Reactivity
Human, Mouse (Murine), Rat (Rattus)
73
50
42
2
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
70
3
Clonality
Polyclonal
Conjugate
This BRE antibody is un-conjugated
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
54
26
24
19
17
13
9
4
3
3
1
1
1
1
Options
Purpose Rabbit Anti-BRE Antibody,
Plasmids, Primers & others Plasmids, Primers & others BRE products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name BRE (BRE Antibody Abstract)
Background

Target Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

Gene Symbol: BRE

Gene ID 9577
UniProt Q9NXR7
Pathways Positive Regulation of Response to DNA Damage Stimulus
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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