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Synonyms: NR1B1,Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein,Nuclear receptor subfamily 1 group B member 1,Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form,RAR alpha,RAR,RAR-alpha,rara,RARA,RARalpha,RARalpha1,Retinoic acid nuclear receptor alpha variant 1,Retinoic acid nuclear receptor alpha variant 2,Retinoic acid receptor alpha,Retinoic acid receptor alpha polypeptide
Background: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.