Synonyms: bHLHe37,Class E basic helix-loop-helix protein 37,MODED,mycn,MYCN,N myc,N myc proto oncogene protein,N-myc proto-oncogene protein,Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene,Neuroblastoma MYC oncogene,NMYC,NMYC proto oncogene protein,ODED,Oncogene NMYC,pp65/67,V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog,v myc avian myelocytomatosis viral related oncogene neuroblastoma derived,v myc myelocytomatosis viral related oncogene neuroblastoma derived
Background: This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.