Synonyms: Epididymis luminal protein 210,Epididymis secretory protein Li 34,Epididymis secretory protein Li 96,HCNP,HCNPpp,HEL 210,HEL S 34,HEL S 96,Hippocampal cholinergic neurostimulating peptide,Neuropolypeptide h3,PBP,PEBP,PEBP 1,PEBP-1,Pebp1,PEBP1,Phosphatidylethanolamine binding protein,Phosphatidylethanolamine binding protein 1,Prostatic binding protein,Prostatic-binding protein,R kip,Raf kinase inhibitor protein,Raf kinase inhibitory protein,RKIP
Background: This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome.