Synonyms: Alpha-CP1,Heterogeneous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein X,hnRNP E1,hnRNP-E1 ,hnRNP-X ,HNRPE1,HNRPX,nucleic acid binding protein sub 2.3,Nucleic acid- binding protein SUB2.3,Nucleic acid-binding protein SUB2.3,PCBP1,PCBP1,poly(rC) binding protein 1,Poly(rC)-binding protein 1,rCbinding protein 1
Background: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.