PCBP1 antibody (Poly(rC) Binding Protein 1)

Details for Product anti-PCBP1 Antibody No. ABIN6566930
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
80
25
16
6
6
3
3
3
1
1
Host
Rabbit
56
16
8
Clonality
Polyclonal
Conjugate
This PCBP1 antibody is un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
69
44
18
3
3
2
1
Options
Immunogen A synthetic peptide of human PCBP1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name PCBP1 (PCBP1 Antibody Abstract)
Background

Synonyms: Alpha-CP1,Heterogeneous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein E1,heterogenous nuclear ribonucleoprotein X,hnRNP E1,hnRNP-E1 ,hnRNP-X ,HNRPE1,HNRPX,nucleic acid binding protein sub 2.3,Nucleic acid- binding protein SUB2.3,Nucleic acid-binding protein SUB2.3,PCBP1,PCBP1,poly(rC) binding protein 1,Poly(rC)-binding protein 1,rCbinding protein 1

Background: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Molecular Weight

Observed_MW: 38kDa

Calculated_MW: 37kDa

Gene ID 5093
UniProt Q15365
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Poly(rC) Binding Protein 1 (PCBP1) antibody (ABIN6566930) Western blot analysis of extracts of various cell lines, using PCBP1 antibody.
Image no. 2 for anti-Poly(rC) Binding Protein 1 (PCBP1) antibody (ABIN6566930) Immunohistochemistry of paraffin-embedded human stomach using PCBP1 antibody.