Synonyms: 47 kDa mannose 6-phosphate receptor-binding protein,47 kDa MPR binding protein,47 kDa MPR-binding protein,Cargo selection protein TIP47,M6PRBP 1,M6PRBP1,Mannose 6 phosphate receptor binding protein 1,Mannose-6-phosphate receptor-binding protein 1,MGC11117,MGC2012,MPR binding protein 47 kDa,Perilipin 3,Perilipin-3,Perilipin3,Placental protein 17,PLIN3,PLIN3,pp17,Tail interacting protein 47 kD,TIP47
Background: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.