Synonyms: CDKN1A activated kinase 6,EC 220.127.116.11,p21 activated protein kinase 6,p21 protein (Cdc42/Rac)-activated kinase 6,p21(CDKN1A) activated kinase 6,p21-activated kinase 6,p21activated kinase 6,PAK 5,PAK 6,PAK-5,PAK-6,PAK5,Pak6,PAK6,Serine threonine protein kinase PAK 6,Serine/threonine protein kinase PAK 6,Serine/threonine protein kinase PAK6,Serine/threonine-protein kinase PAK 6
Background: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.