This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
Synonyms: dJ734G22.2, NAPP2, NF E2 associated polypeptide 2, Peroxin 14, Peroxin-14, Peroxisomal biogenesis factor 14, Peroxisomal membrane anchor protein PEX14, Peroxisomal membrane anchor protein Pex14p, Peroxisomal membrane protein PEX14, pex14, PEX14_HUMAN, Pex14p, PTS1 receptor docking protein, PTS1 receptor-docking protein.