PFKFB3 antibody (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3) (AA 440-490)

Details for Product anti-PFKFB3 Antibody No. ABIN6944520
Antigen
  • IPFK2
  • PFK2
  • E330010H22Rik
  • iPFK-2
  • uPFK-2
  • PFKFB3
  • zgc:73257
  • wu:fc31e01
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog
  • PFKFB3
  • Pfkfb3
  • pfkfb3.S
  • pfkfb3
  • PTRG_09894
  • Tsp_06710
Epitope
AA 440-490
44
17
15
15
10
5
3
3
3
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
150
111
102
4
3
3
3
1
1
Host
Rabbit
145
6
Clonality
Polyclonal
Conjugate
This PFKFB3 antibody is un-conjugated
9
7
7
7
7
7
7
7
7
5
5
5
5
5
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
68
67
33
33
23
9
9
3
3
2
1
1
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human PFKFB3
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PFKFB3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PFKFB3/ PFK2 (PFKFB3 Antibody Abstract)
Background

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]


Synonyms: 6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase, 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3, 6-bisphosphatase, 6-P2ase 3, 6-P2ASE brain/placenta-type isozyme, 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme, 6PF 2-K/Fru 2,6 P2ase 3, 6PF-2-K/Fru-2, F263_HUMAN, fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase, Fructose-2, Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase, iPFK 2, iPFK-2, IPFK2, PFK/FBPase 3, PFK2, PFKFB3, Renal carcinoma antigen NY REN 56, Renal carcinoma antigen NY-REN-56, uPFK 2.
Gene ID 5209
UniProt Q16875
Pathways AMPK Signaling, Regulation of Carbohydrate Metabolic Process
Application Notes IHC-P(1:200-400), IF(IHC-P)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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