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INPP5D antibody (Inositol Polyphosphate-5-Phosphatase, 145kDa) (AA 701-800) (HRP) Primary Antibody

INPP5D Reactivity: Human, Mouse, Monkey ELISA, WB Host: Rabbit Polyclonal HRP
Catalog No. ABIN700924
$442.20
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    INPP5D
    Binding Specificity
    • 20
    • 17
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 701-800
    Reactivity
    • 84
    • 58
    • 38
    • 19
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Monkey
    Host
    • 83
    • 3
    Rabbit
    Clonality
    • 74
    • 12
    Polyclonal
    Conjugate
    • 35
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This INPP5D antibody is conjugated to HRP
    Application
    • 43
    • 22
    • 20
    • 12
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity
    Cow, Horse, Pig, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SHIP1
    Isotype
    IgG
  • Application Notes
    WB 1:300-1000
    ELISA 1:500-1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
    Preservative
    Gentamicin sulfate
    Precaution of Use
    This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    4 °C
    Storage Comment
    Store at 4 °C
    Expiry Date
    12 months
  • Target
    INPP5D
    Alternative Name
    SHIP1 (INPP5D Antibody Abstract)
    Synonyms
    INPP5D, 256.t00004, 13.t00027, ship, ship1, AI323613, SHIP, SHIP-1, SHIP1, s-SHIP, SIP-145, hp51CN, inositol polyphosphate-5-phosphatase D, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, inositol polyphosphate 5-phosphatase, inositol polyphosphate-5-phosphatase D L homeolog, INPP5D, LOC100446045, inpp5d, EHI_159880, EHI_153490, inpp5d.L, LOC100380693, Inpp5d
    Background

    SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

    Subcellular location: Cytoplasm, Cell membrane

    Synonyms: Inositol polyphosphate 5 phosphatase of 145 kDa, 4, 5-trisphosphate 5-phosphatase 1, hp51CN, hSHIP, Inositol polyphosphate 5 phosphatase 145 kDa, Inositol polyphosphate 5 phosphatase, Inositol polyphosphate 5 phosphatase D, Inositol polyphosphate-5-phosphatase of 145 kDa, INPP 5D, INPP5D, INPP5D protein, MGC104855, MGC142140, MGC142142, p150 ship, p150Ship, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1, Phosphatidylinositol-3, SH2 containing inositol 5 phosphatase, SH2 containing inositol phosphatase isoform b, SH2 domain containing inositol 5' phosphatase 1, SH2 domain containing inositol phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol-5''-phosphatase 1, SHIP 1, SHIP-1, SHIP1, SHIP1_HUMAN, Signaling inositol polyphosphate 5 phosphatase SIP 145, Signaling inositol polyphosphate 5 phosphatase SIP145, SIP 145, SIP-145, SIP145.

    Gene ID
    3635
    Pathways
    TCR Signaling, BCR Signaling
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