CD51/CD61 antibody

Catalog No. ABIN7013947

Product Details anti-CD51/CD61 Antibody

Target: CD51/CD61 (ITGAV/ITGB3) (ITGAV/ITGB3)

Reactivity: Human, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD51/CD61 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)

Specificity: The mouse monoclonal antibody 23C6 recognizes an extracellular epitope on CD51/CD61 complex, that is expressed mainly on human osteoclasts, but also e.g. on placenta, or melanoma cell lines. The epitope is native and sensitive to fixation. In chicken this antibody can be used to selectively identify the thrombocytes.

No Cross-Reactivity: Cow, Pig, Rabbit

Purification: Purified by protein-A affinity chromatography

Immunogen: A cell suspension containing osteoclasts from osteoclastomas

Clone: 23C6

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.

Target Details for CD51/CD61

Target: CD51/CD61 (ITGAV/ITGB3) (ITGAV/ITGB3)

Alternative Name: CD51/CD61 (ITGAV/ITGB3 Products)

Synonyms: CD51 antibody, MSK8 antibody, VNRA antibody, VTNR antibody, integrin subunit alpha V antibody, ITGAV antibody

Background:

Description: CD51/CD61 (integrin alpha5beta3), also known as osteoclast functional antigen, serves as a vitronectin receptor, and binds also to fibronectin, fibrinogen, thrombospondin, osteopontin, collagen, and von Willebrand factor. Expression of this antigen increases with melanoma progression. In healthy individuals CD51/CD61 is expressed mainly on osteoclasts, placenta, and endothelial cells, at lower levels on platelets and macrophages.

Other names: VNRA, MSK8, ITGB3, ITGAV, Integrin alpha5beta3, OFA, VR