SSTR2 antibody (Extracellular)

Catalog No. ABIN7043765

Product Details anti-SSTR2 Antibody

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Binding Specificity: AA 30-43, Extracellular

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)

Purpose: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2

Specificity: Extracellular, N-terminus

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse - identical, human- 12,14 amino acid residues identical

Characteristics: Anti-Somatostatin Receptor Type 2 (extracellular) Antibody is directed against the N-terminal domain of the rat SSTR2. Anti-Somatostatin Receptor Type 2 (extracellular) Antibody (ABIN7043765, ABIN7045268 and ABIN7045269)), can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize SSTR2 from mouse, human and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)GSNQTEPYYDMTSN, corresponding to amino acid residues 30-43 of rat SSTR2

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Comment:

Cited Application: IHC

Negative Control: BLP-SR006

Blocking Peptide: BLP-SR006

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Alternative Name: SSTR2 (SSTR2 Products)

Background: SSTR2, SS2R, Smstr2, SRIF1A,Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner.1,2Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner.2Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors.4In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.

Alternative names: Somatostatin Receptor Type 2, SSTR2, SS2R, Smstr2, SRIF1A

Gene ID: 54305

NCBI Accession: NM_001050

UniProt: P30680