DKK2 antibody

Catalog No. ABIN7091038

Product Details anti-DKK2 Antibody

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DKK2 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Human,Mouse

Immunogen: Recombinant human DKK2.

Clone: J3F5

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DKK2

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Alternative Name: DKK2 (DKK2 Products)

Background:

Synonyms: Dickkopf 2, Dickkopf gene 2, Dickkopf homolog 2, Dickkopf related protein 2, Dickkopf-2, Dickkopf-related protein 2, Dickkopf2, DKK 2, Dkk-2, DKK2_HUMAN, hDkk 2, hDkk-2, hDkk2.

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene ID: 27123

UniProt: Q9UBU2

Pathways: WNT Signaling