Ataxin 1 antibody (pSer776)

Catalog No. ABIN7138699

Product Details anti-Ataxin 1 Antibody

Target: Ataxin 1 (ATXN1)

Binding Specificity: pSer776

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 776(R-W-S(p)-A-P) derived from Human Ataxin 1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Ataxin 1

Target: Ataxin 1 (ATXN1)

Alternative Name: ATXN1 (ATXN1 Products)

Background:

Background: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

Aliases: alternative ataxin1 antibody, Ataxin-1 antibody, ATX1 antibody, ATX1_HUMAN antibody, Atxn1 antibody, D6S504E antibody, OTTHUMP00000016065 antibody, SCA1 antibody, Spinocerebellar ataxia type 1 protein antibody

UniProt: P54253

Pathways: Synaptic Membrane