NDC8 (AA 1-249) antibody (FITC)

Catalog No. ABIN7157663

Product Details

Target: NDC8

Binding Specificity: AA 1-249

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kinetochore protein NDC80 homolog protein (1-249AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: NDC8

Background:

Background: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Aliases: from Entrez Gene , antibody, HEC antibody, Highly expressed in cancer antibody, Highly expressed in cancer protein antibody, Highly expressed in cancer rich in leucine heptad repeats antibody, HsHec1 antibody, hsNDC80 antibody, Kinetochore associated 2 antibody, Kinetochore associated protein 2 antibody, Kinetochore protein Hec1 antibody, Kinetochore protein NDC80 homolog antibody, Kinetochore-associated protein 2 antibody, KNTC2 antibody, ndc80 antibody, NDC80 homolog kinetochore complex component antibody, NDC80 kinetochore complex component homolog antibody, NDC80, S. cerevisiae, homolog of antibody, NDC80_HUMAN antibody, Retinoblastoma associated protein HEC antibody, Retinoblastoma-associated protein HEC antibody, TID3 antibody

UniProt: O14777