Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Clusterin antibody

CLU Reactivity: Human WB, ELISA, ICC, IHC (p) Host: Mouse Monoclonal Hs-3 unconjugated
Catalog No. ABIN94264
  • Target See all Clusterin (CLU) Antibodies
    Clusterin (CLU)
    Reactivity
    • 88
    • 28
    • 28
    • 12
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 83
    • 38
    • 7
    • 5
    • 2
    • 1
    Mouse
    Clonality
    • 96
    • 38
    • 1
    Monoclonal
    Conjugate
    • 79
    • 25
    • 17
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Clusterin antibody is un-conjugated
    Application
    • 111
    • 68
    • 57
    • 22
    • 21
    • 19
    • 16
    • 12
    • 8
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    The mouse monoclonal antibody Hs-3 recognizes human clusterin (apolipoprotein J), a conserved secreted glycoprotein.
    No Cross-Reactivity
    Cat, Cow, Dog, Pig
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization.
    Clone
    Hs-3
    Isotype
    IgG1
    Top Product
    Discover our top product CLU Primary Antibody
  • Application Notes
    Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: Sertoli cells.
    Western blotting: Recommended dilution: 1 μg/mL, positive material: seminal plasma.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Capková, Geussová, Peknicová: "New monoclonal antibody to human apolipoprotein J." in: Folia biologica, Vol. 48, Issue 1, pp. 40-2, (2002) (PubMed).

  • Target
    Clusterin (CLU)
    Alternative Name
    Clusterin (CLU Products)
    Background
    Clusterin,Clusterin (APO J, SGP-2, TRPM-2, SP-40, pADHC-9, CLJ, T64, GP III, XIP8) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30 % of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. It is a conserved secreted glycoprotein expressed by a wide range of tissues and being implicated in many physiological processes, including e.g. lipid transportation, complement inhibition, tissue remodeling, membrane recycling, or clearence of cellular debris. It is nearly ubiqitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. Clusterin is able to bind and form complexes with numerous partners (immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin etc.) and is expressed in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. A genuine function of clusterin is still enigmatic.,Complement-associated protein SP-40, Complement cytolysis inhibitor, CLI, CLU, NA1/NA2, Apolipoprotein J, Apo-J, TRPM-2, KBP1, KUB1, CLI, AAG4, APOJ, SGP2
    Gene ID
    1191
    UniProt
    P10909
    Pathways
    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
You are here:
Support