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anti-Human BCL2L1 Antibodies:
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Human Polyclonal BCL2L1 Primary Antibody for ELISA, IF (p) - ABIN675129
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
Show all 6 Pubmed References
Human Polyclonal BCL2L1 Primary Antibody for IHC (p), WB - ABIN5518741
Zhou, Zhang, Li, Hao, Liu, Wang: Azithromycin synergistically enhances anti-proliferative activity of vincristine in cervical and gastric cancer cells. in Cancers 2013
Show all 4 Pubmed References
Human Polyclonal BCL2L1 Primary Antibody for IP, WB - ABIN223050
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment. in International journal of immunopathology and pharmacology 2008
Show all 3 Pubmed References
Human Polyclonal BCL2L1 Primary Antibody for IHC - ABIN965653
Cheng, Levine, Boise, Thompson, Hardwick: Bax-independent inhibition of apoptosis by Bcl-XL. in Nature 1996
Show all 3 Pubmed References
Human Monoclonal BCL2L1 Primary Antibody for FACS - ABIN135024
Chittenden, Harrington, OConnor, Flemington, Lutz, Evan, Guild: Induction of apoptosis by the Bcl-2 homologue Bak. in Nature 1995
Show all 8 Pubmed References
Human Polyclonal BCL2L1 Primary Antibody for IHC (p), WB - ABIN3043033
Cui, Li, Xu, Zhang, Sun, Chen: Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. in Molecular medicine reports 2018
Show all 2 Pubmed References
Human Polyclonal BCL2L1 Primary Antibody for IF, IHC - ABIN4368418
Liu, Huang, Zeng, Chen, Huang, Guo, Liu, Xu, Mo, Li: Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. in Journal of cancer research and clinical oncology 2011
Human Monoclonal BCL2L1 Primary Antibody for WB - ABIN1882212
Ban, Eckhart, Weninger, Mildner, Tschachler: Identification of a human cDNA encoding a novel Bcl-x isoform. in Biochemical and biophysical research communications 1998
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hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 (show BCL2 Antibodies) family proteins, and interacts with anti-apoptotic BCL-2 (show BCL2 Antibodies) family proteins MCL-1 (show MCL1 Antibodies) and BCL-xL
Study demonstrated that lncRNA-HEIH regulates miR (show MLXIP Antibodies)-939 expression through transcriptional repression of Bcl-xL promoting colorectal tumorigenesis.
Results showed that the expressions of RIP2 (show ARHGEF28 Antibodies) and BclxL were positively correlated with the malignant grade of astrocytoma. RIP2 (show ARHGEF28 Antibodies) promoted human glioblastoma cell proliferation by inducing expression of BclxL.
BCL-XL has a role in modulating RAS signalling to favor breast cancer cell stemness
Bcl-xL degradation during endoplasmic reticulum stress-induced apoptosis is mediated by RNF183.RNF183 ubiquitinates Bcl-xL.
BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma.
inhibition of the BCL2 family member BCLxL resulted in nanomolar potency against human synovial sarcoma cell lines and 50% tumor reduction in a genetically engineered mouse model
In this study, we investigated whether APG (show SMAD1 Antibodies)-1252-12A inhibits the growth of five leukemia cell lines in a concentration- or time-dependent manner by MTS (show TIMM8A Antibodies) assay.APG-1252-12A is a Bcl-2 (show BCL2 Antibodies) homology (BH)-3 mimetic that specifically binds to Bcl-2 (show BCL2 Antibodies) and Bcl-xl, which has shown efficacy in some Bcl-2 (show BCL2 Antibodies) dependent hematological cancers
inhibition of Bcl-xL induces significantly more apoptosis in IDH1 (show IDH1 Antibodies)-mutated cells than in wild-type IDH1 (show IDH1 Antibodies) cells.
CCAT1 is upregulated in docetaxel-resistant lung adenocarcinoma cells; its oncogenic function depends on sponging of let-7c, which releases Bcl-xl, promoting the acquisition of chemoresistance and epithelial-to-mesenchymal transition phenotypes
Depletion of miR (show MLXIP Antibodies)-34a facilitated endothelial cell growth and blocked apoptosis in AS by upregulating Bcl-2 (show BCL2 Antibodies), offering a promising avenue for AS therapy.
targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling.
GATA-3 (show GATA3 Antibodies) participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2 (show RUNX2 Antibodies).
this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl
Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway.
Proapoptotic proteins BIM (show BCL2L11 Antibodies) and PUMA (show BBC3 Antibodies) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.
BMP4 (show BMP4 Antibodies) promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4 (show BMP4 Antibodies)-Smad1 (show SMAD1 Antibodies)/5/8-Id1 (show ID1 Antibodies) signaling in the presence of FGF-2 (show FGF2 Antibodies).
We propose that the GC-induced mitochondrial accumulation of Bax (show BAX Antibodies) and the interaction between the GR and Bim (show BCL2L11 Antibodies), Bcl-xL and Bak (show BAK1 Antibodies) could play a role in the regulation of thymocyte apoptosis.
Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord.
amplification and characterization of partial regions of exons 2 and 3 of the bovine BCL2L1 gene
Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling.
interleukin-6 (show IL6 Antibodies), endothelin ET-1 (show EDN1 Antibodies), and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bcl-xL was significantly decreased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Antibodies) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF Antibodies), IL-6 (show IL6 Antibodies), IL-12p40, IL-1beta (show IL1B Antibodies), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 Antibodies) and bcl2L1.
This study leads to conclude that BCLXL peak expression at the zygotic genome activation phase may be a requirement for embryo development
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2L1 transcripts and protein depending on luteal stage.
repression of radiation-induced apoptosis by overexpression of Bcl-xL during embryonic development depends upon the timing of its expression and post-translational events that enable the protein to become effective
The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors
Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Delta113p53 functions to antagonize p53 (show TP53 Antibodies)-induced apoptosis via activating bcl2L
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
apoptosis regulator Bcl-X
, bcl-2-like protein 1
, protein phosphatase 1, regulatory subunit 52
, B-cell leukemia/lymphoma x
, anti-apoptosis regulatory protein
, B cell lymphoma 2 like
, B cell lymphoma like X
, BCL2-like protein 1
, anti-apoptotic Bcl-xL
, BCLX protein
, BCL2-like 1
, apoptosis regulator R11
, Bcl-xL-like protein 1