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Human BIRC2 Protein expressed in Escherichia coli (E. coli) - ABIN2003966
Blankenship, Varfolomeev, Goncharov, Fedorova, Kirkpatrick, Izrael-Tomasevic, Phu, Arnott, Aghajan, Zobel, Bazan, Fairbrother, Deshayes, Vucic: Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1). in The Biochemical journal 2008
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we conclude that DMBT1 (show DMBT1 Proteins) by binding with CRNDE and c-IAP1 associated with PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) pathway is crucial for GBC carcinogenesis, and targeting this pathway may be pivotal in the treatment of GBC.
These results reveal an additional level of regulation of the stability and the activity of E2F1 (show E2F1 Proteins) by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase (show MUL1 Proteins) cIAP1.
High cIAP1 expression is associated with colorectal cancer.
the cytoplasmic retinoic acid receptor gamma (show RARG Proteins) (RARgamma) controls receptor-interacting protein (show RIPK1 Proteins) kinase (show CDK7 Proteins) 1 (RIP1 (show UQCRFS1 Proteins))-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.
High cIAP1 expression is associated with Lung Tumorigenesis.
These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO (show IKBKG Proteins) to prevent cIAP1-induced NEMO (show IKBKG Proteins) polyubiquitination.
The baseline tumor necrosis factor (show TNF Proteins) tumor (TNFalpha (show TNF Proteins)) expression correlates with the sensitivity to Inhibitors of apoptosis proteins (IAPs) antagonist T-3256336.
cIAP1-induced mitophagy led to dysfunctional mitochondria that resulted in abrogation of mitochondrial oxygen consumption rate along with the decrease in ATP levels. The ubiquitination of cIAP1 was found to be the critical regulator of mitophagy.
Overexpression of cIAP1 is associated with glioma.
High expression of cIAP1 is associated with triple-negative breast cancer.
Drugs targeting XIAP (show XIAP Proteins) and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 (show RIPK1 Proteins) and contain high levels of TNFalpha (show TNF Proteins).
Results identify IGF2BP1 (show B4GALNT2 Proteins) as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.
Identify xIAP (show XIAP Proteins) and cIAP1 as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
NFATc1 (show NFATC1 Proteins) mRNA expression is negatively regulated by inhibitor of apoptosis protein 2 during osteoclastogenesis.
cIAP1 expression protects macrophages from Rip1 (show RALBP1 Proteins)-dependent necroptotic cell death and facilitates pathogen control.
cIAP1 plays a critical role in beta-cell survival under endoplasmic reticulum stress: by promoting ubiquitination and degradation of C/EBP homologous protein (CHOP (show DDIT3 Proteins))
Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3 (show BIRC3 Proteins)) impaired caspase-1 (show CASP1 Proteins) activation after spontaneous or agonist-induced inflammasome assembly.
These findings identify critical role of cIAP1, cIAP2 (show BIRC3 Proteins) and Yap1 (show YAP1 Proteins) co-expression in mammary carcinogenesis
Murine IAP1 (show BIRC3 Proteins) is alternatively spliced at intron 6-7, generating protein isoforms with significantly different functional properties compared to the full-length mIAP1, in vitro.
Data show that apoptosis caused by an IAP (show ALPI Proteins) antagonist compound is blocked by the caspase 8 (show CASP8 Proteins) inhibitor crmA and that IAP (show ALPI Proteins) antagonists activate NF-kappaB (show NFKB1 Proteins) signaling via inhibtion of cIAP1.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IAP homolog B
, NFR2-TRAF signalling complex protein
, RING finger protein 48
, TNFR2-TRAF-signaling complex protein 2
, apoptosis inhibitor 1
, baculoviral IAP repeat-containing 2
, baculoviral IAP repeat-containing protein 2
, inhibitor of apoptosis protein 2
, apoptosis inhibitor 2
, inhibitor of apoptosis protein
, IAP homolog
, inhibitor of T-cell apoptosis protein
, inhibitor of apoptosis 1
, baculoviral IAP repeat-containing 3
, inhibitor of apoptosis protein-1
, inhibitor of apoptosis protein 1
, bZ1P14.6.2 (baculoviral IAP repeat-containing 3 )
, baculoviral IAP repeat containing 2 L homeolog