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anti-Rat (Rattus) BIRC5 Antibodies:
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Cat (Feline) Polyclonal BIRC5 Primary Antibody for ChIP, ELISA - ABIN153009
Blanc-Brude, Yu, Simosa, Conte, Sessa, Altieri: Inhibitor of apoptosis protein survivin regulates vascular injury. in Nature medicine 2002
Show all 319 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for ELISA, FACS - ABIN153038
Zhu, Fukuda, Cordis, Das, Maulik: Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. in FEBS letters 2001
Show all 37 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for ELISA, FACS - ABIN153011
Ansell, Arendt, Grote, Jelinek, Novak, Wellik, Remstein, Bennett, Fielding: Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma. in Leukemia 2004
Show all 20 Pubmed References
Cat (Feline) Polyclonal BIRC5 Primary Antibody for ELISA, IHC (fro) - ABIN268915
Hauf, Cole, LaTerra, Zimmer, Schnapp, Walter, Heckel, van Meel, Rieder, Peters: The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. in The Journal of cell biology 2003
Show all 19 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for BP, ELISA - ABIN269272
Geddis, Kaushansky: Megakaryocytes express functional Aurora-B kinase in endomitosis. in Blood 2004
Show all 15 Pubmed References
Hamster Monoclonal BIRC5 Primary Antibody for ICC, IF - ABIN153037
Adida, Haioun, Gaulard, Lepage, Morel, Briere, Dombret, Reyes, Diebold, Gisselbrecht, Salles, Altieri, Molina: Prognostic significance of survivin expression in diffuse large B-cell lymphomas. in Blood 2000
Show all 16 Pubmed References
Cat (Feline) Polyclonal BIRC5 Primary Antibody for ELISA, ICC - ABIN268914
Kennedy, ODriscoll, Purcell, Fitz-Simons, McDermott, Hill, OHiggins, Parkinson, Linehan, Clynes: Prognostic importance of survivin in breast cancer. in British journal of cancer 2003
Show all 14 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for IF, IHC - ABIN6712254
Wang, Han, Yang, Yang, Guo, Zhang, Pan, Xia, Chen: Effect of interaction of magnetic nanoparticles of Fe₃O₄ and artesunate on apoptosis of K562 cells. in International journal of nanomedicine 2011
Show all 11 Pubmed References
Mouse (Murine) Polyclonal BIRC5 Primary Antibody for WB - ABIN3043511
Li, Zhao, Lu, Li, Yang, Wu, Liu: Notch-1 signaling promotes the malignant features of human breast cancer through NF-?B activation. in PLoS ONE 2014
Show all 9 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for WB - ABIN3043195
Zhang, Lu, Hou, Hu, Wang: The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells. in Tumour biology 2014
Show all 9 Pubmed References
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Overexpressed in tumors, BIRC5 is associated with unfavorable overall survival in triple negative lung adenocarcinomas.
High surviving expression is associated with melanoma.
The role of PTEN in the process is potentially significant providing a suppressor balance to the p53/ survivin complex.
Survivin -31G>C polymorphism is associated with sporadic colorectal cancer (CRC) risk in the Southern Chinese population. The -31G wild-type genotypes and GC, GG genotypes are the independent protective factors against sporadic CRC excluding those with a BMI >/=28.0 kg/m2, family cancer history, and premenopausal.
the novel functionalized SWCNT loaded with DOX and survivin siRNA was successfully synthesized, and the nanocomplex exhibited effective antitumor effects both in vitro and in vivo, thereby providing an alternative strategy for the codelivery of antitumor drugs and genes.
differential expression of survivin and its splice variants may perhaps act as a diagnostic marker in patients suffering from thyroid cancer (review).
Survivin expression was not associated with breast cancer recurrence in this study.
Single nucleotide polymorphism genotyping for -31G/C (rs9904341) polymorphism in the survivin promoter region is found in 54.1% of the breast cancer patients compared with 46.5% of controls from a north Indian population. The presence of homozygous CC genotype is associated with increased risk for development of breast cancer.
These data showed that miR-338-5p, one of the target miRNA biomarkers, was significantly downregulated in TE-4R. Ectopic overexpression of miR-338-5p induced apoptosis and sensitivity to radiation treatment by interfering with survivin, which is a known inhibitor of apoptosis.
The survivin rs9904341 polymorphism may be associated with the risk of cancer either overall or in the Asian population.[meta-analysis]
Our work shows for the first time that YY1 represses survivin transcription by physically interacting with the survivin promoter. Furthermore, YY1 appears to contribute to basal survivin transcriptional activity, indicating that disruption of its binding may in part contribute to survivin overexpression after cellular stress events including chemotherapy and radiotherapy.
The results suggest that RAD51 and survivin are potent markers that determine the therapeutic efficacy of proton beam therapy in patients with pancreatic cancer
BIRC5 may be responsible for the condition of stem cell pluripotency.
We identified 16 potentially druggable candidates. Among them, NEK2, BIRC5, and TOP2A were also found to be amplified in breast cancer, suggesting that they could act as strategic players in the obese-deregulated transcriptome.
Mcl-1 and Survivin can be considered as promising molecular targets for the treatment of AML. The combination treatment with etoposide, and siRNA-mediated silencing of corresponding genes may be a novel strategy in chemoresistance AML treatment.
Shorter overall survival was associated with BIRC5 and DNMT3B overexpression highlighting its potential as novel prognostic marker for penile cancer.
these findings suggest that BIRC5 supports long-term survival of HIV-1-infected cells
Overexpression of survivin in gallbladder cancer suggests its possible role and association with poor prognosis. But XIAP has not been found to be associated with gallbladder carcinogenesis.
Enforced expression of miR-494 decreased the expression of survivin, and thus promoted the TRAIL-induced mitochondria collapse and apoptosis pathway in gastric cancer cells.
Survivin in the signal downstream of VEGFR2 played an important role in esophageal cancer cell survival.
The existence of Pcdh7-BIRC5 signaling cascade in the cortical neurons and represent a potential therapeutic area for further investigation.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.
Survivin also attenuates DNA damage related to PARP activation and inhibits TNFalpha-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta and was found to be highly expressed during mucosal healing following intestinal inflammation
SurvivinT34A combined with arsenic trioxide induces a loss of mitochondria membrane potential
Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC) cancer stem cell formation and cancer SCC development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 and ki67.
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL-mediated beta cell proliferation via Akt, STAT5-PIM and ERK signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
NR4A1 protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP expression.
Studies indicate the importance of survivin in Sonic hedgehog (SHH)-driven medulloblastoma (MB).
the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin
Both HIF1-alpha and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy.
survivin2 is important in maintaining hematopoietic stem and lineage committed cells during zebrafish development, by virtue of its antiapoptotic activity in a caspase dependent and cell autonomous fashion.
Survivin 2 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha
, baculoviral IAP repeat containing 5b
, baculoviral IAP repeat-containing 5B
, survivin 2
, baculoviral IAP repeat containing 5 S homeolog
, baculoviral IAP repeat-containing 5, gene 2