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anti-Rat (Rattus) BIRC5 Antibodies:
anti-Human BIRC5 Antibodies:
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Cat (Feline) Polyclonal BIRC5 Primary Antibody for ChIP, ELISA - ABIN153009
Blanc-Brude, Yu, Simosa, Conte, Sessa, Altieri: Inhibitor of apoptosis protein survivin regulates vascular injury. in Nature medicine 2002
Show all 319 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for ELISA, FACS - ABIN153038
Zhu, Fukuda, Cordis, Das, Maulik: Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. in FEBS letters 2001
Show all 37 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for ELISA, FACS - ABIN153011
Ansell, Arendt, Grote, Jelinek, Novak, Wellik, Remstein, Bennett, Fielding: Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma. in Leukemia 2004
Show all 20 Pubmed References
Human Monoclonal BIRC5 Primary Antibody for BP, ELISA - ABIN269272
Geddis, Kaushansky: Megakaryocytes express functional Aurora-B kinase in endomitosis. in Blood 2004
Show all 15 Pubmed References
Hamster Monoclonal BIRC5 Primary Antibody for ICC, IF - ABIN153037
Adida, Haioun, Gaulard, Lepage, Morel, Briere, Dombret, Reyes, Diebold, Gisselbrecht, Salles, Altieri, Molina: Prognostic significance of survivin expression in diffuse large B-cell lymphomas. in Blood 2000
Show all 16 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for IF, IHC - ABIN6712254
Wang, Han, Yang, Yang, Guo, Zhang, Pan, Xia, Chen: Effect of interaction of magnetic nanoparticles of Fe₃O₄ and artesunate on apoptosis of K562 cells. in International journal of nanomedicine 2011
Show all 11 Pubmed References
Mouse (Murine) Polyclonal BIRC5 Primary Antibody for WB - ABIN3043511
Li, Zhao, Lu, Li, Yang, Wu, Liu: Notch-1 signaling promotes the malignant features of human breast cancer through NF-?B activation. in PLoS ONE 2014
Show all 9 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for WB - ABIN3043195
Zhang, Lu, Hou, Hu, Wang: The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells. in Tumour biology 2014
Show all 9 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for ICC, IF - ABIN153036
Liu, Brouha, Grossman: Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. in Oncogene 2004
Show all 9 Pubmed References
Human Polyclonal BIRC5 Primary Antibody for IHC (p), ELISA - ABIN3042792
Cai, Liu, Zhao, Wan, Hu, Zhou, Chen: Expressions of survivin and vascular endothelial growth factor in a Murine model of proliferative retinopathy. in International journal of ophthalmology 2012
Show all 8 Pubmed References
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
The protooncogene survivin was identified as a functional target of miR3305p, and this was validated using a luciferase reporter assay.
MicroRNA-203 is highly expressed in non-small cell lung cancer (NSCLC) , and is closely related to tumor stage, lymph node metastasis, distant metastasis and poor prognosis of NSCLC patients. It is concluded that microRNA-203 promotes the progression of NSCLC via regulating survivin expression.
A positive feedback loop was identified between mitochondrial fission and Notch signaling pathway in triple negative breast cancer (TNBC) cells, where elevated Notch signaling enhanced Drp1-mediated mitochondrial fission, while Drp1-mediated mitochondrial fission in turn promoted the activation of Notch signaling, which ultimately promoted the cell survival of TNBC via increasing survivin expression level.
MiR-218 targeted and inhibited BIRC5 expression, weakened caspase inhibition by BIRC5, and facilitated U2OS osteosarcoma cell apoptosis.
survivin isoforms are regulated both by different GLI proteins and BIRC5 polymorphisms in ovarian cancer.
miR-195 targets cyclin D3 to cause cell cycle arrest at the G1 phase and that miR-195 targets survivin to induce apoptosis and senescence in NSCLC cells. Overexpression of cyclin D3 or survivin reverses the effects of miR-195 in NSCLC cells.
Results show nuclear survivin protein expression in colorectal cancer (CRC) patients with the CC genotype higher than in patient with the GG and GC genotypes suggesting that C allele of - 31G/C polymorphism in survivin might be cooperative in CRC development.
The expressions of HIF-1alpha, surviving, and VEGF played important roles in the occurrence, invasion, and metastasis of hepatocarcinoma.
dysregulation of miR-195-5p/-218-5p/BIRC5 axis predicts a poor prognosis in patients with gastric cancer
Plasma survivin levels are reduced in obstructive sleep apnea, are relate to disease severity, and are associated with high CRP levels.
BIRC5 can be used as a cardiac risk score if it is used with other highly accurate means of stratification.
Data sugest that targeting survivin using honokiol in combination with radiation therapy (RT) may provide novel therapeutic opportunities.
Nuclear expression of survivin is a factor for a poor prognosis in glioblastoma patients. Subcellular localization of survivin can help to predict overall survival in glioblastoma patients treated with the standard protocol.
Survivin Promoter Polymorphism (-31 C/G) is associated with Oral Cancer.
in acute myeloid leukemia, WT1 is associated with increased bone marrow blasts and higher Flt3-ITD mutations, while survivin is associated with higher white blood cell count; both show less remission and survival
Overexpressed in tumors, BIRC5 is associated with unfavorable overall survival in triple negative lung adenocarcinomas.
High surviving expression is associated with melanoma.
The role of PTEN in the process is potentially significant providing a suppressor balance to the p53/ survivin complex.
Survivin -31G>C polymorphism is associated with sporadic colorectal cancer (CRC) risk in the Southern Chinese population. The -31G wild-type genotypes and GC, GG genotypes are the independent protective factors against sporadic CRC excluding those with a BMI >/=28.0 kg/m2, family cancer history, and premenopausal.
the novel functionalized SWCNT loaded with DOX and survivin siRNA was successfully synthesized, and the nanocomplex exhibited effective antitumor effects both in vitro and in vivo, thereby providing an alternative strategy for the codelivery of antitumor drugs and genes.
The existence of Pcdh7-BIRC5 signaling cascade in the cortical neurons and represent a potential therapeutic area for further investigation.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.
Survivin also attenuates DNA damage related to PARP activation and inhibits TNFalpha-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta and was found to be highly expressed during mucosal healing following intestinal inflammation
SurvivinT34A combined with arsenic trioxide induces a loss of mitochondria membrane potential
Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC) cancer stem cell formation and cancer SCC development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 and ki67.
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
Survivin directly participates in PRL-mediated beta cell proliferation via Akt, STAT5-PIM and ERK signalling pathways during pregnancy
Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.
Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury
NR4A1 protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP expression.
Studies indicate the importance of survivin in Sonic hedgehog (SHH)-driven medulloblastoma (MB).
the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin
Both HIF1-alpha and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy.
survivin2 is important in maintaining hematopoietic stem and lineage committed cells during zebrafish development, by virtue of its antiapoptotic activity in a caspase dependent and cell autonomous fashion.
Survivin 2 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha
, baculoviral IAP repeat containing 5b
, baculoviral IAP repeat-containing 5B
, survivin 2
, baculoviral IAP repeat containing 5 S homeolog
, baculoviral IAP repeat-containing 5, gene 2