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calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2 (show MMP2 Proteins)/TGF-beta1 (show TGFB1 Proteins) pathway.
indicate that calpain-1 (show CAPN1 Proteins) and calpain-2 play opposite roles in high increased intraocular pressure-induced ischemic injury
Results indicate that calpain-1 (show CAPN1 Proteins) and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 Proteins) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins), and triggers neurodegenerative cascades.
these findings identify ASAP2 as a new target of Selk-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.
ENaC (show SCNN1A Proteins) activity is regulated by calpain-2 proteolysis of MARCKS (show MARCKS Proteins).
calpains and calpastatin (show CAST Proteins) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.
Leukocyte calpain-1 (show CAPN1 Proteins)/calpain-2 deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
These results suggest that TRPV1 (show TRPV1 Proteins)/Ca(2 (show CA2 Proteins)+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.
Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.
LOX-1 (show OLR1 Proteins) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 (show CAPN1 Proteins) and -2.
The results of the present study suggested that miR93 regulated MMP1 (show MMP1 Proteins) and collagen I expression in fibroblasts via calpain2. miR93 mediated collagen expression in stress urinary incontinence via calpain2.
Hyperactivated m-calpain induced cytoplasmic accumulation of truncated topoisomerase IIalpha in doxorubicin resistant T47D cells.
Results find that overexpression of hTau increases intracellular calcium, which in turn activates calpain-2 and induces degradation of alpha4 nAChR (show CHRNA4 Proteins).
m-calpain translocated as the result of calcium influx was involved in DNA double-strand breaks repair, especially in the non-homologous end-joining pathway through proteolysis of nuclear Ku80. Cleaved Ku80 was still able to form a heterodimer with Ku70 and enhance DNA repair activity.
3 novel loci associated with serum alpha-carotene concentrations among a population that consumed a controlled diet. While replication is necessary, the CAPN2/CAPN8 (show CAPN8 Proteins) locus provides compelling evidence for an association with serum alpha-carotene concentrations and may suggest a relationship with the development and progression of cancers.
The inhibitory effects of BMP4 (show BMP4 Proteins) on PDGF (show PDGFA Proteins)-induced cell proliferation, collagen synthesis, and calpain-2 activation are impaired in pulmonary artery smooth muscle cells from pulmonary arterial hypertension patient.
Calpain-2 upregulates PDGF (show PDGFA Proteins)-induced Akt (show AKT1 Proteins) phosphorylation in pulmonary vascular remodeling via an intracrine TGF-beta1 (show TGFB1 Proteins)/mTORC2 (show CRTC2 Proteins) mechanism.
the expression of CAPN2 was elevated in prostate cancer tissues than that in normal control tissues.
our findings suggest that the gene/protein expression of both CAPN1 (show CAPNL1 Proteins) and CAPN2, as well as the ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) genes and related proteins, could be molecular factors associated with more invasive tumor behavior in squamous cell laryngeal cancer.
m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
The cleavage of NCX1 (show SLC8A1 Proteins) by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2 (show CA2 Proteins)+) overload
characteristic properties of ER membrane m-calpain (MCp (show CD46 Proteins)), calpastatins and lumen m-calpain (LCp (show KLHDC2 Proteins)) and a brief comparative study between MCp (show CD46 Proteins) and LCp (show KLHDC2 Proteins)
Calpain-2 plays an important role in lung endothelial cell migration and proliferation.
The Decreased expression of calpain 2 mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
80 kDa M-calpain subunit
, CANP 2
, calcium-activated neutral proteinase 2
, calpain M-type
, calpain-2 catalytic subunit
, calpain-2 large subunit
, cysteine proteinase
, m-calpain 80 kDa large subunit
, m-calpain large subunit
, calpain 2, large [catalytic] subunit
, calpain 2, large subunit
, calpain large polypeptide L2
, calpain, large polypeptide L2
, calpain II