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Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.(1) Myelin sheaths generated by oligodendrocytes are able to facilitate fast neuronal action potential conduction along the axon.
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(1) Bradl M, Lassmann H. Oligodendrocytes: biology and pathology. Acta Neuropathol. 2010 Jan;119(1):37-53. doi: 10.1007/s00401-009-0601-5. Epub 2009 Oct 22. PMID: 19847447; PMCID: PMC2799635.
Barbarese, E. et al. Expression and localization of myelin basic protein in oligodendrocytes and transfected fibroblasts. J. Neurochem. 51, 1737–45 (1988).
Pozniak, C. D. et al. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc. Natl. Acad. Sci. U. S. A. 107, 21795–800 (2010).
Scolding, N. J. et al. Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation. J. Neuroimmunol. 22, 169–176 (1989).