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Human alpha Fetoprotein Protein expressed in Human - ABIN934756
Lee, Nguyen, Sim: A nanoplasmonic biosensor for label-free multiplex detection of cancer biomarkers. in Biosensors & bioelectronics 2015
Show all 2 Pubmed References
Human alpha Fetoprotein Protein expressed in Human - ABIN377076
Jee, Ang, Cha, Ang, Ling, Lim, Lee: Combinatorial bead-based peptide libraries improved for rapid and robust screenings. in Combinatorial chemistry & high throughput screening 2014
Human alpha Fetoprotein Protein expressed in Human - ABIN934453
Lee, Lee: Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. in Biochemical and biophysical research communications 2012
Human alpha Fetoprotein Protein expressed in Cell culture - ABIN573558
Mikhaylova, Schumacher, Borutzki, Neumann, Macharadze, El-Mousleh, Wahle, Zenclussen, Kreutz: Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide. in BMC research notes 2014
Peak preoperative serum alpha-fetoprotein to total tumor volume predicts recurrence of hepatocellular carcinoma.
the results suggest that AFP may positively regulate cell proliferation by enhancing the apoptosis resistance via effect on TGF-beta and p53/Bax/caspase-3 signaling pathway in HepG2 cells. As such, the knockdown of AFP gene should be further investigated in vivo as a novel approach to hepatocellular carcinoma treatment.
Aberrant CTNNB1 expression was seen in a substantial proportion of our hepatocellular carcinoma (HCC) cases. CTNNB1-positive HCC was associated with normal AFP levels, unicentric tumors, well-differentiated histology, and an unfavorable outcome.
Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.
Cases of ovarian ovarian Sertoli-Leydig cell tumors (SLCTs) with elevated serum AFP should be sampled extensively to look for foci of intestinal-type glands, the likely source of the alpha fetoprotein (AFP) elevation in some of these neoplasms.
In HBV-related cirrhosis, the combination of miR-122, AFP and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Examination of AFP over time has great predictive and prognostic value for managing advanced gastric cancer. For those with markedly elevated AFP, triplet regimens may be a better choice.
Low expression of AFP is associated with recurrence of hepatocellular carcinoma.
High-levels of PIVKA-II in at-risk patients is an indicator of hepatocellular carcinoma (HCC)development in two-year time. CONCLUSIONS: Our data showed that PIVKA-II effectively increases the detection rate of HCC was a valid complement to AFP and image examination in HCC surveillance
Unspecific AFP elevations occur in about 2% of pure testicular seminoma patients.
serum level in the second trimester an important indicator of fetal surface malformations
HCC [hepatocellular carcinoma] patients who are sero-positive for DCP [Des-gamma-carboxyprothrombin] and sero-negative for AFP[Alpha-fetoprotein] have significantly higher levels of serum ALT[alanine aminotransferase]; serum ALT levels may be of diagnostic importance in AFP-negative, HBV-related HCC [hepatitis B virus-related hepatocellular carcinoma] patients.
Higher baseline serum AFP levels independently predicted a lower sustained viral response to antivirals among patients with chronic hepatitis C.
Computer modeling shows the identification of potential binding sites of lysophospholipids (LP) receptors on the AFP third domain receptor binding fragment. AFP might bind not only to the LPL receptors, but also to LPLs themselves since AFP binds medium and long chain fatty acids. It is proposed that some of the activities ascribed to AFP might be due in part to the presence of bound LPLs and/or their receptors. [review]
AFP may be an important molecule acting against paclitaxel-inhibited proliferation and induced apoptosis in hepatocellular carcinoma cells via repressing the activity of caspase-3 and stimulating the expression of Ras and Survivin.
PIVKA II, when combined with AFP, may be considered as a screening test for hepatocellular carcinoma due to its high negative predictive value.
Identification of the distinct impact of circulating tumor derived AFP on NK-cell function and viability may be crucial to developing a strategy to ameliorate hepatocellular carcinoma patient NK-cell functional deficits.
The detection of ALT, AFP, AFP-L3, and GP73 has a certain guiding significance to predict the risk of hepatocellular carcinoma in hepatic cirrhosis patients
Antibody therapy targeted at AFP-producing tumor cells showed an inhibitory effect on the PI3K/AKT pathway via the liberation, restoration and functional stabilization of PTEN. PTEN simultaneously induced both P53 activation and intracellular translocation of GLUT1, since these are closely associated with PTEN.
Incorporation AFP status into the BCLC staging system to modify the recommended treatment of patients with stage C hepatocellular carcinoma.
endogenous AFP expression in the perinatal liver is reduced in the absence of beta-catenin, suggesting that beta-catenin regulates AFP during liver development.
Findings indicate that AFP expressed under experimental cryptorchid conditions plays a role as a regulatory factor in spermatogenesis and in hepatic generation.
AFP mRNA and VEGF-C mRNA in peripheral blood were significantly correlated with recurrence and metastasis of hepatocellular carcinoma.
A DEHP treatment-induced phenotype was identified with lack of glycogen accumula-tion and intracytoplasmic localization of beta-catenin which was associated with increased AFP gene expression.
The deficits observed in parental behavior of AFP knockout females could not be explained by any changes in olfactory function, novelty recognition or anxiety
Foxa1 acts as a pioneer transcription factor in de novo activation of Afp, by exploiting a lack of methylation at juxtaposed transposed elements
The level of AFP mRNA in peripheral blood may indicate recurrence and/or metastasis after curative resection of hepatocellular carcinoma.
AFP affects cell proliferation by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras p21 genes
A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor.
The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3
AFP has a role in female fertility, but not in male fertility or survival, in mice
mouse and human alpha-fetoprotein enhancers are strikingly different
AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation
30-kDa protein is a novel isoform of AUF1 family and is the main component of the DAP-II complex that binds to the DAS sequence
The sex difference in the ability to show preovulatory LH surges depends on the prenatal actions of estrogens in the male hypothalamus, is lost in Afp(-/-) females.
data indicate that this enhancer region is required for alpha-fetoprotein and albumin activation early in liver development and alpha-fetoprotein reactivation during liver regeneration
Equine alpha-fetoprotein seems to be an important indicator of fetal well-being in horses.
This study confirmed that alpha-fetoprotein (AFP) is present in the fetal fluids of mares during the third trimester of pregnancy; experimentally induced placentitis was associated with an elevation in maternal plasma concentrations of AFP.
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
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