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Human alpha Fetoprotein Protein expressed in Human - ABIN934756
Lee, Nguyen, Sim: A nanoplasmonic biosensor for label-free multiplex detection of cancer biomarkers. in Biosensors & bioelectronics 2015
Show all 2 Pubmed References
Human alpha Fetoprotein Protein expressed in Human - ABIN377076
Jee, Ang, Cha, Ang, Ling, Lim, Lee: Combinatorial bead-based peptide libraries improved for rapid and robust screenings. in Combinatorial chemistry & high throughput screening 2014
Human alpha Fetoprotein Protein expressed in Human - ABIN934455
Lee, Lee: Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. in Biochemical and biophysical research communications 2012
Human alpha Fetoprotein Protein expressed in Cell culture - ABIN573558
Mikhaylova, Schumacher, Borutzki, Neumann, Macharadze, El-Mousleh, Wahle, Zenclussen, Kreutz: Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide. in BMC research notes 2014
Peak preoperative serum alpha-fetoprotein to total tumor volume predicts recurrence of hepatocellular carcinoma.
the results suggest that AFP may positively regulate cell proliferation by enhancing the apoptosis resistance via effect on TGF-beta (show TGFB1 Proteins) and p53 (show TP53 Proteins)/Bax (show BAX Proteins)/caspase-3 (show CASP3 Proteins) signaling pathway in HepG2 cells. As such, the knockdown of AFP gene should be further investigated in vivo as a novel approach to hepatocellular carcinoma treatment.
Aberrant CTNNB1 (show CTNNB1 Proteins) expression was seen in a substantial proportion of our hepatocellular carcinoma (HCC (show FAM126A Proteins)) cases. CTNNB1 (show CTNNB1 Proteins)-positive HCC (show FAM126A Proteins) was associated with normal AFP levels, unicentric tumors, well-differentiated histology, and an unfavorable outcome.
Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.
Cases of ovarian ovarian Sertoli-Leydig cell tumors (SLCTs) with elevated serum AFP should be sampled extensively to look for foci of intestinal-type glands, the likely source of the alpha fetoprotein (AFP) elevation in some of these neoplasms.
In HBV-related cirrhosis, the combination of miR (show MLXIP Proteins)-122, AFP and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Examination of AFP over time has great predictive and prognostic value for managing advanced gastric cancer. For those with markedly elevated AFP, triplet regimens may be a better choice.
Low expression of AFP is associated with recurrence of hepatocellular carcinoma.
High-levels of PIVKA-II in at-risk patients is an indicator of hepatocellular carcinoma (HCC (show FAM126A Proteins))development in two-year time. CONCLUSIONS: Our data showed that PIVKA-II effectively increases the detection rate of HCC (show FAM126A Proteins) was a valid complement to AFP and image examination in HCC (show FAM126A Proteins) surveillance
Unspecific AFP elevations occur in about 2% of pure testicular seminoma patients.
endogenous AFP expression in the perinatal liver is reduced in the absence of beta-catenin (show CTNNB1 Proteins), suggesting that beta-catenin (show CTNNB1 Proteins) regulates AFP during liver development.
Findings indicate that AFP expressed under experimental cryptorchid conditions plays a role as a regulatory factor in spermatogenesis and in hepatic generation.
AFP mRNA and VEGF-C (show VEGFC Proteins) mRNA in peripheral blood were significantly correlated with recurrence and metastasis of hepatocellular carcinoma.
A DEHP treatment-induced phenotype was identified with lack of glycogen (show GYS1 Proteins) accumula-tion and intracytoplasmic localization of beta-catenin (show CTNNB1 Proteins) which was associated with increased AFP gene expression.
The deficits observed in parental behavior of AFP knockout females could not be explained by any changes in olfactory function, novelty recognition or anxiety
Foxa1 (show FOXA1 Proteins) acts as a pioneer transcription factor in de novo activation of Afp, by exploiting a lack of methylation at juxtaposed transposed elements
The level of AFP mRNA in peripheral blood may indicate recurrence and/or metastasis after curative resection of hepatocellular carcinoma.
AFP affects cell proliferation by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras (show HRAS Proteins) p21 genes
A murine Nkx2.8 (show NKX2-6 Proteins) was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor (show NR5A2 Proteins).
The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (show FOXA1 Proteins)
Equine alpha-fetoprotein seems to be an important indicator of fetal well-being in horses.
This study confirmed that alpha-fetoprotein (AFP) is present in the fetal fluids of mares during the third trimester of pregnancy; experimentally induced placentitis was associated with an elevation in maternal plasma concentrations of AFP.
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
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