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These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation.
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results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor
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We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis.
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These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population
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Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy.
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Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied.
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The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study.
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the anatomical localization of Hreceptors suggests a complex interaction that could both enhance and inhibit dopaminergic neurotransmission; tt is conceivable that Hreceptors can moderate the development and maintenance of drug addiction.
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The A280V mutation reduces the signalling efficacy of the human H3 receptor; this effect may be relevant to the pathophysiology of disorders associated with the mutation
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Report synthesis/functional characterization of imbutamine analogs as histamine H3 agonists.
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In this review, we focus on the role of histamine and its receptors in the treatment of Alzheimer's disease.
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[review] The H1, H2, and H3 receptors are all involved in recovery of neurological function when extracellular histamine is gradually increasing, after cerebral ischemia.
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mRNA expression of HRH-3 localized in large pigmented neurons is significantly decreased in the substantia nigra of Parkinson's patients.
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ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R.
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Significant association of HRH3 with antipsychotic efficacy was detected.
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study identified novel functional properties in terms of voltage sensitivities and deactivation rates, which differed between the histamine hH3445, hH3365, and H4 receptors
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Histamine H3 receptor levels are unchanged in subcortical ischemic vascular dementia and mixed dementias in all brain areas studied.
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The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling.
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Data suggest that V-allele genotypes in the H3 receptor gene increase inactive receptors, enhancing inhibition of negative feedback mechanism on the H3 receptor and increasing histamine release, correlating with migraine attacks in susceptible patients.
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This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity.
