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Human Polyclonal HRH3 Primary Antibody for IF (p), IHC (p) - ABIN701890
Møller, Kirkeby, Vikeså, Nielsen, Caye-Thomasen: Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2015
Human Polyclonal HRH3 Primary Antibody for IHC (p), WB - ABIN271101
Dagli, Goksu, Eryilmaz, Mocan Kuzey, Bayazit, Gun, Gocer: Expression of histamine receptors (H(1), H(2), and H(3)) in the rabbit endolymphatic sac: an immunohistochemical study. in American journal of otolaryngology 2007
Cow (Bovine) Polyclonal HRH3 Primary Antibody for ELISA - ABIN4219531
Cricco, Mohamad, Sambuco, Genre, Croci, Gutiérrez, Medina, Bergoc, Rivera, Martín: Histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2008
These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation.
results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor
We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis.
These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population
Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy.
Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied.
The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study.
the anatomical localization of Hreceptors suggests a complex interaction that could both enhance and inhibit dopaminergic neurotransmission; tt is conceivable that Hreceptors can moderate the development and maintenance of drug addiction.
The A280V mutation reduces the signalling efficacy of the human H3 receptor; this effect may be relevant to the pathophysiology of disorders associated with the mutation
Report synthesis/functional characterization of imbutamine analogs as histamine H3 agonists.
In this review, we focus on the role of histamine and its receptors in the treatment of Alzheimer's disease.
[review] The H1, H2, and H3 receptors are all involved in recovery of neurological function when extracellular histamine is gradually increasing, after cerebral ischemia.
mRNA expression of HRH-3 localized in large pigmented neurons is significantly decreased in the substantia nigra of Parkinson's patients.
ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R.
Significant association of HRH3 with antipsychotic efficacy was detected.
study identified novel functional properties in terms of voltage sensitivities and deactivation rates, which differed between the histamine hH3445, hH3365, and H4 receptors
Histamine H3 receptor levels are unchanged in subcortical ischemic vascular dementia and mixed dementias in all brain areas studied.
The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling.
Data suggest that V-allele genotypes in the H3 receptor gene increase inactive receptors, enhancing inhibition of negative feedback mechanism on the H3 receptor and increasing histamine release, correlating with migraine attacks in susceptible patients.
This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity.
Study shows that striatal signaling is regulated by the H3R histamine receptor in a mouse model of tic pathophysiology. observations support the hypothesis that constitutive activity of upregulated H3R receptors in the histidine decarboxylase-KO model mediates the observed alterations in baseline medium spiny neuron signaling.
The H3 receptor in the dorsal striatum is a contributor to repetitive behavioral pathology.
H3R activation with the agonist R-(-)-alpha-methylhistamine to produce a unique time- and cell type-dependent profile of molecular signaling events in the striatum.
H3R is an important regulator of sensorimotor gating, and the lack of H3R significantly modifies striatal dopaminergic
Data show that knockout of histamine receptor H3 (Hrh3 receptor) caused a substantial reduction of free-running activity rhythm amplitude.
These results suggest that H3 receptor may participate in the maintenance of the relaxed state and prevention of over-contraction in mature differentiated myotubes.
Histamine H3 receptors were expressed in mouse beta cells and could play a role in insulin secretion and, possibly, beta cell proliferation.
Hrh3 polymorphisms between EAE-susceptible and resistant SJL and B10.S mice
Greater slow wave sleep increases are found in histamine H3 knock-out mice compared to wild-type mice, consistent with enhanced histamine transmission.
Evidence for the role of histamine H3 receptor was found in alcohol-related behaviors, especially in alcohol drinking and alcohol reward.
An increased expression of H3 receptors in HDC KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine.
These findings demonstrate that manipulation of central histamine H3 receptor by proxyfan can significantly improve glucose excursion by increasing plasma insulin levels via a glucose-independent mechanism.
D(1)-H(3) receptor heteromers work as processors integrating dopamine- and histamine-related signals involved in controlling the function of striatal neurons of the direct striatal pathway.
In this review conditioned place preference induced by alcohol is stronger in histidine decarboxylase-deficient mice than in control mice.
Methamphetamine- and MDMA-induced behavioral changes in Hrh3 knockout mice are reported.
The aim of this work was to investigate the effects of essential splice signals on intron retention in histamine H3 receptors and to identify sequence elements that determine the differences in splicing between rats and mice.
These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice.
Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors.
Data support a protective antiarrhythmic role of histamine H(3)-receptors in myocardial ischemia.
Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
G protein-coupled receptor 97
, G-protein coupled receptor 97
, histamine H3 receptor
, histamine H3 receptor H3L isoform
, histamine receptor H 3
, G protein-coupled receptor