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Critical ischemia is associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 plasma concentrations than in the case of intermittent claudication
genetic polymorphisms in MMP3 and TIMP2 are significantly associated with chronic Achilles tendinopathy risk in a Chinese Han population
TIMP2 is a direct downstream target of miR-552 in osteosarcoma.
study demonstrated that TUG1 promotes the migration and invasion of human adenomyotic epithelial cells, and EGR1/TUG1/EZH2/TIMP2 may be a potential therapeutic target for adenomyosis.
Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome
The tissue's MMP-14/TIMP-2 ratio may regulate the degree of Pro-MMP-2 activation as a determining factor, while the enzymatic activities of MMP-14 and TIMP-2 do not seem to play a key role in aneurysm development.
Study in cohort of donation after circulatory death kidney transplant recipients showed that urinary TIMP-2 is a promising biomarker predicting the occurrence and duration of prolonged functionally defined delayed graft function, whereas IGFBP7 was not sensitive enough in the setting of kidney transplantation.
No significant interactions were noted between the MMP3, MMP8 and TIMP2 genes with ACLR susceptibility despite the known biological interactions between the proteins.
TIMP2 plays an important role in mediating sepsis-induced acute kidney injury (AKI) through regulation of NF-kappaB. These findings reveal the pathogenic role of TIMP2 in AKI and suggest a novel target for the treatment of AKI.
rs8179090 -418 G > C polymorphism in the TIMP-2 gene is not associated with heart failure susceptibility and prognosis in Brazilian population.
TIMP2 as the novel candidate biomarker for poorer outcome of GC patients
A low expression of TIMP2 and TIMP1 is correlated with advanced stages of meningioma.
Study indicated that TIMP-2 rs2277698 was associated with breast cancer susceptibility in Han Chinese women. Also, TIMP-2 mRNA was found to be under-expressed in breast cancer.
Imbalance in the metalloproteinase (MMP2, MMP9) to inhibitor tissue expression (TIMP1, TIMP2) in the vessel wall (the cross-sections of the internal thoracic artery, radial artery, and saphenous vein) might predispose to aortocoronary graft failure after coronary artery bypass grafting. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.
This study indicated that the MMP-2 (-1306C/T) polymorphism, in combination with the TIMP-2 (-418G/C) polymorphism, contributes to acne vulgaris susceptibility in the Chinese Han population.
no significant correlation discovered between the rate of change in MMP-2 or MMP-2/TIMP-2 ratio and tumor grade or any clinicopathological variables in head and neck squamous cell carcinoma
The current study suggests that the variation of TIMP2 gene and its interaction with MMP9 gene might be associated with male infertility.
TIMP2 plays a role in SZ etiology.
These results suggest that EZH2 inhibits TIMP2 expression via H3K27me3 and DNA methylation, which relieve the repression of MMP and facilitate ovarian cancer invasion and migration.
Low TIMP2 expression is associated with decrease in radiosensitivity of lung cancer.
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
Results describe distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.
Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.
the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance
Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle
Results describe the isolation of matrix metalloproteinase 2 (MMP-2) from the MMP-2/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 and the complex itself.
oxidants inactivate TIMP-2, and the resulting activation of MMP-2 subsequently inhibits Na+ dependent Ca2+ uptake in the microsomes
TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.
Results suggest that MMP-2, MMP-9, and TIMP-2 mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.
We have solved the 2.0 A crystal structure of the complex between the catalytic domain of human MMP-13 (cdMMP-13) and bovine TIMP-2.
legumain and TIMP-2 mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy
placental content differed between mares retaining fetal membranes and controls
The pathology of laminitis is associated with increased and lowered transcription of MMP-14 and TIMP-2, respectively.
Current study elucidated the distinct nature of the inhibitory effect on IS as a result of overexpressed miR-410 whereby the conferral of neuroprotection was observed in oxidative stress-induced apoptosis post IS through the TIMP2-dependent repression of the MAPK pathway in mice.
Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of extracellular matrix, leading to tumor cell invasion and progression
the protein expression levels of TIMP-2 and PBEF in cloned placentae, were examined.
demonstrate that TIMP-2 plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis
Further investigation of MMP2 inhibitors of TIMP2/TIMP4 showed an upregulated TIMP2 expression, but not TIMP4. low-dose pre-radiation attenuates the skin inflammation and ROS production induced by medium-dose UV radiation
TIMP2 and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function
Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK signaling pathway.
High TIMP2 expression is associated with liver fibrosis.
TIMP2 promotes kidney injury through metalloproteinase (MMP)2 activation
Gene expression of Mmp-12 and Mmp-13, and Timp-1 was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2, and Mmp-9 expression was modest.
Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta, PAI-1 and RAGE in diabetic db/db cells.
This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.
results suggest that genetic ablation of tissue inhibitor of matrix metalloproteinase-2 decreases the expression of pro-angiogenic matrix metalloproteinases-2 and increases anti-angiogenic factors resulting in ventricular remodelling and heart failure
In neural stem cells, TIMP-2 acts as key effector of the proneurogenic response to inducing stimuli such as Marimastat.
Spread of Lewis lung carcinoma cells from serum to lungs was associated with increased serum content of TIMP-1 and TIMP-2.
Results show enhanced expression and widespread distribution of MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in thymus from infected animals.
Chuanxiong can ameliorate the age changes in aortic morphology, reduce the production of ROS and AGEs in vascular tissue, inhibit MMP-2 activity and regulate MMP-2/TIMP-2 equilibrium.
these findings suggest that reduction of TIMP2 levels and increased angiogenesis are possible primary events in osteoarthritis progression.
Mono-(2-ethylhexyl) phthalate decreases Timp2 expression in Sertoli cells via deactivation of CEBPA and activation of MYC.
The mRNA and protein expression levels of PBEF and TIMP-2 in the placentae of normal mice, were analyzed.
in normal eye development, hydrocortisone could inhibit both the axial elongation and the myopic shift; whereas (2) in lens-induced myopia eye development, hydrocortisone (a) enhanced the axial elongation, myopic shift and sclera thinning; (b) enhanced the MMP-2 expression and decreased TIMP-2 expression
To further study the function of TIMP-2 in development, we utilized zebrafish as an experimental model system
membrane-type 1 metalloproteinase, gelatinase A , and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
, metalloproteinase inhibitor 2
, tissue inhibitor of metalloproteinase 2
, tissue inhibitor of metalloproteinases 2
, collagenase inhibitor
, tissue inhibitor of mettaloproteinase 2
, tissue inhibitor of metalloproteinase-2
, tissue inhibitor of matrix metalloproteinase-2
, metalloproteinase inhibitor TIMP-2