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pre-TCR expression is not essential for thymic differentiation to DP cells or for V-DJbeta suppression
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
The cytoplasmic tail of pTalpha plays a critical role in T lymphocyte development.
pTalpha plays a role in protecting developing thymocytes from DNA damage in mice
the dosage of E2A, HEB, and SCL determines pT alpha gene expression in immature T cells
when in competition with pTalpha, TCRalpha induced defective proliferation, survival, and differentiation of alphabeta T lymphocyte precursors
expression is up-regulated in regulatory T cells
High levels of pre-T cell receptor alpha-chain mRNA splice forms have been demonstrated in immature CD2+CD7+CD3- T cells of the jejunal mucosa, both intraepithelially and in lamina propria.
identified a polyproline-arginine sequence in the pTalpha cytoplasmic tail that interacted in vitro with SH3 domains of the CIN85/CMS family of adaptors, and mediated the recruitment of multiprotein complexes involving all (CMS, CIN85, and CD2BP3) members
The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.
pre T-cell antigen receptor alpha
, pre-T-cell receptor alpha chain