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Our data suggested that high expression of PAX2 could be associated with better survival in estrogen receptor (show ESR1 Proteins) positive tamoxifen-treated breast carcinoma patients.
During the ensuing weeks, the PAX2/FOXA1 boundary progressively extended cranially such that by 21 weeks the entire vaginal epithelium was FOXA1-reactive and PAX2-negative. This observation supports Bulmer's proposal that human vaginal epithelium derives solely from urogenital sinus epithelium
PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1 (show ZFP42 Proteins)
This case unravels a previously unrecognized phenotype of camptodactyly due to a significant skeletal deformity of Papillorenal syndrome with a heterogeneous PAX2 mutation of hexanucleotide duplication.
Mutant p53 and PTEN loss negatively regulated PAX2 and PAX2 re-expression in high-grade serous ovarian cancer cells induced cell death.
The polymorphism rs12266644 of PAX2 might be a risk factor for mullerian duct anomalies in Chinese Han females
PAX2, PAX8 (show PAX8 Proteins), CDX2 (show CDX2 Proteins) immunostains was preformed to the TMA slides.
we demonstrated that miR (show MLXIP Proteins)-497 is decreased in human ovarian cancer tissues and cells, and acts as a tumor suppressor. We also confirmed PAX2 is a target gene of miR (show MLXIP Proteins)-497
Vimentin (show VIM Proteins), Nestin (show NES Proteins) and WT1 (show WT1 Proteins). Sox2 (show SOX2 Proteins) was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE (show ENO2 Proteins).
PAX2 and PAX5 (show PAX5 Proteins) are useful biomarker in the differential diagnosis of lung cancer
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear
Demonstrate the stepwise emergence of hitherto undescribed, differently Pax2/Pax8 (show PAX8 Proteins)- coded anterior and posterior subdomains in the posterior placodal area of mice.
Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program.
Pax2-regulated ISL1 (show ISL1 Proteins) overexpression increases the embryonic ISL1 (show ISL1 Proteins)(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
PAX2 may not be a classical oncogene (show RAB1A Proteins) or tumor suppressor but instead can act in either role by differential regulation of COX2 and/or HTRA1 (show HTRA1 Proteins).
Dicer (show DICER1 Proteins) ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
Pax2 specifies the intermediate mesoderm and renal epithelial cells through epigenetic mechanisms and in part by repressing paraxial mesodermal fate.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1)-Pax2 protein knockout embryos.
a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
Pax2 is required after the establishment of the tubule pronephric anlage, for the expression of several terminal differentiation markers of the pronephric tubule.
pax2 transcription factor cooperates in patterning the Xenopus brain.
Pax2a and Pax8 (show PAX8 Proteins) regulate cell differentiation during sensory placode formation
Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development
pax8 (show PAX8 Proteins) works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 Proteins), a necessary step for further otic development
wnt1 (show WNT1 Proteins) and wnt10b (show WNT10B Proteins) are required to maintain threshold levels of Pax2.1 and Fgf8 (show FGF8 Proteins) at the midbrain-hindbrain boundary.
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Pax2a and Pax8 (show PAX8 Proteins) are the main effectors downstream of Fgf signals in ear formation
pax8 (show PAX8 Proteins) is initially required for normal otic induction, and subsequently pax8 (show PAX8 Proteins), pax2a and pax2b act redundantly to maintain otic fate
Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons.
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
paired box homeotic gene 2
, paired box protein Pax-2
, optic disc coloboma
, paired box gene 2
, paired box protein Pax-2-A
, no isthmus protein
, paired box gene 2.1
, paired box homeotic gene 2a
, paired box protein Pax-2a