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AP-2beta up-regulates the transcription of the CRYAB (show CRYAB Proteins) gene through stabilizing p53 (show TUBB Proteins).
CVAK104 (show SCYL2 Proteins) binds ATP and functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin (show AP2B1 Proteins) subunit of AP2 (show TFAP2A Proteins)
tfap2b and its close relative, tfap2a (show TFAP2A Proteins), play redundant roles in the ectoderm to control skeletogenesis of neural crest cells
Study systematically examined the expression profile of AP-2 (show TFAP2A Proteins) family in the developing mouse and chick spinal cord and found that AP-2alpha (show TFAP2A Proteins) and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha (show TFAP2A Proteins) and AP-2beta have distinct functions in dorsal interneuron specification and differentiation.
AP-2 beta and beta-catenin (show CTNNB1 Proteins) interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo (show PKP1 Proteins) repeats of beta-catenin (show CTNNB1 Proteins).
the Tfap2a (show TFAP2A Proteins) and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a (show PTF1A Proteins).
critical roles for AP-2 (show TFAP2A Proteins) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (show TFAP2A Proteins), Tcfap2b, and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (show TFAP2A Proteins) and Tcfap2b in horizontal and amacrine cell development
Tfap2b is associated with the development and remodeling of mouse ductus arteriosus and limb patterning.
PKD (show PRKD1 PLURAL_@37961@) is thus a common modulator of the DNA binding activity of AP-2alpha (show TFAP2A PLURAL_@37961@) and AP-2beta through their phosphorylation for negative regulation of the ABCA1 (show ABCA1 PLURAL_@37961@) and adiponectin (show ADIPOQ PLURAL_@37961@) genes expression, respectively.
postprandial activation of PKCmicro plays a role in disordered postprandial adipocytokine expression through AP-2beta.
Whereas AP-2alpha (show TFAP2A Proteins)/beta transcription factors are in vivo not required for the onset or maintenance of noradrenergic differentiation, their essential survival functions are demonstrated for sympathetic progenitors and noradrenergic neurons.
Data suggest that AP-2beta plays critical roles in the epinephrine phenotype and maturation of adrenal chromaffin cells.
Tfap2beta, Et-1 (show EDN1 Proteins), and Hif2alpha (show EPAS1 Proteins) act in a transcriptional network during ductal smooth muscle development. Disruption of this pathway may contribute to patent ductus arteriosus by affecting development of smooth muscle in the ductus arteriosus.
AP-2 beta and beta-catenin (show CTNNB1 Proteins) interact both in vitro through GST (show SLCO6A1 Proteins) pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo (show PKP1 Proteins) repeats of beta-catenin (show CTNNB1 Proteins).
Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1 (show AGTR1 Proteins)), transcription factor AP-2 beta (TFAP2B), and tumor necrosis factor (show TNF Proteins) receptor-associated factor 1 (TRAF1 (show TRAF1 Proteins)) have been reported to be associated with the incidence of PDA in preterm infants.
results suggest that TFAP2B is playing a vital role in retaining retinoic acid responsiveness and mediating noradrenergic neuronal differentiation in neuroblastoma (show ARHGEF16 Proteins).
TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK (show EPHB2 Proteins) and VEGF (show VEGFA Proteins)/PEDF (show SERPINF1 Proteins) signaling.
The AP-2beta polymorphism significantly influenced cognitive performance, whereas the MAOA (show MAOA Proteins) and COMT (show COMT Proteins) polymorphisms did not.
A haploinsufficiency effect of TFAP2B could be involved in familial isolated patent ductus arteriosus.
TFAP2B rs987237 and dietary protein/carbohydrate interacted to modify weight maintenance.
genomic GATA4 (show GATA4 Proteins) and TFAP2B missense mutations may be associated with nonfamilial congenital heart disease with diverse clinical phenotypes in patients with congenital heart disease from southern China
Under energy restriction, TFAP2B may modify the effect of dietary fat intake on weight loss and waist reduction
The findings suggest the lack of involvement of known mutations of TFAP2B with syndromic or nonsyndromic CHDs in Mysore patients
Expression of TFAP2beta and TFAP2gamma (show TFAP2C Proteins) genes in Xenopus laevis.
LH and insulin (show INS Proteins) stimulate transcription of -976/+31 bp 5 (show HSPD1 Proteins)'-upstream cis (show CISH Proteins)-acting region of porcine CYP17 (show CYP17A1 Proteins) gene. Maximal transcriptional responsiveness requires proximal Sp1 (show SP1 Proteins) and AP-2-like (show TFAP2D Proteins) sequences -193 to -180 bp 5 (show HSPD1 Proteins)' upstream of transcriptional start site.
Data demonstrates the colocalization of MARK with AP-2 and clathrin, as well as other MARK-interacting proteins such as PAK5.
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
, activating enhancer-binding protein 2 beta
, activating enhancer-binding protein 2-beta
, transcription factor AP-2-beta
, activating enhancer binding protein 2 beta
, transcription factor AP-2 beta
, AP2 transcription factor
, beta adaptin
, beta adaptin drosophila 1