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LH and insulin (show INS Proteins) stimulate transcription of -976/+31 bp 5 (show HSPD1 Proteins)'-upstream cis (show CISH Proteins)-acting region of porcine CYP17 (show CYP17A1 Proteins) gene. Maximal transcriptional responsiveness requires proximal Sp1 (show SP1 Proteins) and AP-2-like (show TFAP2D Proteins) sequences -193 to -180 bp 5 (show HSPD1 Proteins)' upstream of transcriptional start site.
Data demonstrates the colocalization of MARK with AP-2 and clathrin, as well as other MARK-interacting proteins such as PAK5.
tfap2b and its close relative, tfap2a (show TFAP2A Proteins), play redundant roles in the ectoderm to control skeletogenesis of neural crest cells
CVAK104 (show SCYL2 Proteins) binds ATP and functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin (show AP2B1 Proteins) subunit of AP2 (show TFAP2A Proteins)
AP-2beta up-regulates the transcription of the CRYAB (show CRYAB Proteins) gene through stabilizing p53 (show TUBB Proteins).
these findings reveal that the AP-2 (show TFAP2A Proteins) genes have a major function in mammalian neural crest development, influencing patterning of the craniofacial skeleton
AP-2beta is required in the periocular mesenchyme for normal development of the anterior segment of the eye.
Study systematically examined the expression profile of AP-2 (show TFAP2A Proteins) family in the developing mouse and chick spinal cord and found that AP-2alpha (show TFAP2A Proteins) and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha (show TFAP2A Proteins) and AP-2beta have distinct functions in dorsal interneuron specification and differentiation.
AP-2 beta and beta-catenin (show CTNNB1 Proteins) interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo (show PKP1 Proteins) repeats of beta-catenin (show CTNNB1 Proteins).
the Tfap2a (show TFAP2A Proteins) and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a (show PTF1A Proteins).
critical roles for AP-2 (show TFAP2A Proteins) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (show TFAP2A Proteins), Tcfap2b, and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (show TFAP2A Proteins) and Tcfap2b in horizontal and amacrine cell development
Tfap2b is associated with the development and remodeling of mouse ductus arteriosus and limb patterning.
PKD is thus a common modulator of the DNA binding activity of AP-2alpha and AP-2beta through their phosphorylation for negative regulation of the ABCA1 and adiponectin genes expression, respectively.
postprandial activation of PKCmicro plays a role in disordered postprandial adipocytokine expression through AP-2beta.
Whereas AP-2alpha (show TFAP2A Proteins)/beta transcription factors are in vivo not required for the onset or maintenance of noradrenergic differentiation, their essential survival functions are demonstrated for sympathetic progenitors and noradrenergic neurons.
previously, only 10 different pathogenic variants in the TFAP2B gene have been associated with the Char syndrome and patent ductus arteriosus (human gene mutation database subscription). We have thus identified the 11th mutation, namely, c.851T>C, p. Leu284Ser, which cosegregates with the phenotype.
study demonstrates that AP-2beta promotes tumor growth and predicts poor prognosis, and may represent a potential therapeutic target for breast cancer.
Reduced TFAP2B expression in EC was significantly associated with high grade (OR=2.2 for well, moderate vs. poor), stage (OR=2.5 for I vs. IV), histology (OR=1.8 for serous vs. endometrioid), distant metastasis (OR=2.4 for positive vs. negative) (all p-values<0.05).
TFAP2B mutation is associated with tooth abnormalities.
AP-2 beta and beta-catenin (show CTNNB1 Proteins) interact both in vitro through GST (show SLCO6A1 Proteins) pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo (show PKP1 Proteins) repeats of beta-catenin (show CTNNB1 Proteins).
Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1 (show AGTR1 Proteins)), transcription factor AP-2 beta (TFAP2B), and tumor necrosis factor (show TNF Proteins) receptor-associated factor 1 (TRAF1 (show TRAF1 Proteins)) have been reported to be associated with the incidence of PDA in preterm infants.
results suggest that TFAP2B is playing a vital role in retaining retinoic acid responsiveness and mediating noradrenergic neuronal differentiation in neuroblastoma (show ARHGEF16 Proteins).
TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK (show EPHB2 Proteins) and VEGF (show VEGFA Proteins)/PEDF (show SERPINF1 Proteins) signaling.
The AP-2beta polymorphism significantly influenced cognitive performance, whereas the MAOA (show MAOA Proteins) and COMT (show COMT Proteins) polymorphisms did not.
A haploinsufficiency effect of TFAP2B could be involved in familial isolated patent ductus arteriosus.
Expression of TFAP2beta and TFAP2gamma (show TFAP2C Proteins) genes in Xenopus laevis.
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
, activating enhancer-binding protein 2 beta
, activating enhancer-binding protein 2-beta
, transcription factor AP-2-beta
, activating enhancer binding protein 2 beta
, transcription factor AP-2 beta
, AP2 transcription factor
, beta adaptin
, beta adaptin drosophila 1