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anti-Human TJP1 Antibodies:
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Human Polyclonal TJP1 Primary Antibody for IF (cc), IF (p) - ABIN675024
Gu, Xue, Wei, Zhang, Li: Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats. in Neuroscience letters 2011
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Human Polyclonal TJP1 Primary Antibody for ELISA, ICC - ABIN6266146
Zou, Xiang, Wang, Peng, Wei: Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model. in BioMed research international 2017
Show all 2 Pubmed References
Human Polyclonal TJP1 Primary Antibody for ICC, IF - ABIN4359733
Gangl, Reininger, Bernhard, Campana, Pree, Reisinger, Kneidinger, Kundi, Dolznig, Thurnher, Valent, Chen, Vrtala, Spitzauer, Valenta, Niederberger: Cigarette smoke facilitates allergen penetration across respiratory epithelium. in Allergy 2009
Show all 2 Pubmed References
Human Polyclonal TJP1 Primary Antibody for IF - ABIN2192206
Balda, Anderson: Two classes of tight junctions are revealed by ZO-1 isoforms. in The American journal of physiology 1993
Human Polyclonal TJP1 Primary Antibody for ELISA, WB - ABIN4359730
Zhong, Deane, Ali, Parisi, Shapovalov, OBanion, Stojanovic, Sagare, Boillee, Cleveland, Zlokovic: ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. in Nature neuroscience 2008
Human Polyclonal TJP1 Primary Antibody for ICC, IF - ABIN4359735
McIntyre, Alev, Mechael, Salci, Lee, Fiebig-Comyn, Guezguez, Wu, Sheng, Bhatia: Expansive generation of functional airway epithelium from human embryonic stem cells. in Stem cells translational medicine 2014
Dysfunction of the miR (show MLXIP Antibodies)-455-TJP1 axis is involved in bladder cancer cell growth and metastasis.
The tight junction protein ZO-1 exists in stretched and folded conformations within epithelial cells, depending on actomyosin-generated force.
miR103 was upregulated in CRC (show CALR Antibodies). Overexpression of miR103 promoted CRC (show CALR Antibodies) cell proliferation and migration in vitro, whereas downregulation of miR103 inhibited cell proliferation and migration. ZO1 was identified as a direct target of miR103, revealing its expression to be inversely correlated with miR103 expression in CRC (show CALR Antibodies) samples.
SHANK3 expression correl (show SHANK3 Antibodies)ated with ZO-1 and PKCepsilon in colonic tissue of (show SHANK3 Antibodies) patients with Crohn's disease. The expression level of SHANK3 affects ZO-1 expres (show SHANK3 Antibodies)sion and the barrier function in intestina (show PRKCE Antibodies)l epithelial cells.
These results indicate the varying effects of 7-oxygenated cholesterol molecules on the expression and localization of ZO-1 depending on cell types, and suggest the contribution of 7-oxygeneted cholesterol molecules to the structural alteration of tight junctions.
CTR (show CALCR Antibodies) activates AKAP2 (show AKAP2 Antibodies)-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3 (show CLDN3 Antibodies).
the Ras signaling pathway is involved in HIV-1 Tat (show TAT Antibodies)-induced changes in ZO-1 and NEP (show MME Antibodies).
decreased interaction between ZO-1 and occludin (show OCLN Antibodies) might contribute to the epiphora occurred in the transplanted submandibular glands
integration of claudin-2 (show CLDN2 Antibodies), occludin (show OCLN Antibodies) and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.
Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin (show OCLN Antibodies) and zonula occludens 1.
Podocyte-specific deletion of the ZO-2 (show TJP2 Antibodies) gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 (show TJP2 Antibodies) genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 (show TJP2 Antibodies) plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier.
the endothelial barrier was preserved in respiratory epithelium isolated from MCU (show MCU Antibodies)-/- mice after exposure to IL-13 (show IL13 Antibodies). In the ovalbumin (show OVA Antibodies)-model of allergic airway disease, MCU (show MCU Antibodies) deficiency resulted in decreased apoptosis within the large airway epithelial cells. Concordantly, expression of the tight junction protein ZO-1 was preserved, indicative of maintenance of epithelial barrier function
Busulfan treatment down-regulated the epididymal expression of vimentin (show VIM Antibodies) and zonula occludens-1 (ZO-1).
At 3days after the first tamoxifen injection, Akt1 (show AKT1 Antibodies)(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43 (show GJA1 Antibodies)) and connexin-interacting protein zonula occludens-1 (ZO-1). Furthermore, Akt1 (show AKT1 Antibodies)/2 silencing significantly decreased both Cx43 (show GJA1 Antibodies) and ZO-1 expression
Overexpression of SHANK3 (show SHANK3 Antibodies) enhanced ZO-1 expression, and knockdown of SHANK3 (show SHANK3 Antibodies) resulted in decreased expression of ZO-1. Regulation of ZO-1 expression by SHANK3 (show SHANK3 Antibodies) seems to be mediated through a PKCepsilon (show PRKCE Antibodies)-dependent pathway. The expression level of SHANK3 (show SHANK3 Antibodies) affects ZO-1 expression and the barrier function in intestinal epithelial cells in mice.
STAT3 (show STAT3 Antibodies) activation downregulates the ZO-1 and occludin (show OCLN Antibodies) levels and increases the endothelial permeability through the induction of VEGF (show VEGFA Antibodies) production in retinal endothelial cells.
Cx43 (show GJA1 Antibodies) tethers the F-actin cytoskeleton through a ZO-1 linker and supports cell spreading and exploration during locomotion in cerebral endothelial cells.
Expression of Podocalyxin (show PODXL Antibodies), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 (show TJP2 Antibodies) and this correlates with an aberrant submembranous localization of Ezrin (show EZR Antibodies).
Zonula occludens-1, occludin (show OCLN Antibodies) and E-cadherin (show CDH1 Antibodies) expression and organization in salivary glands
cyclic strain modulates both the expression and phosphorylation state of occludin (show OCLN Antibodies) and ZO-1 in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
ZO-1 and occludin (show OCLN Antibodies) are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin (show OCLN Antibodies) at the blastocyst stage.
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.
tight junction protein ZO-1
, zona occludens 1
, zona occludens protein 1
, zonula occludens 1 protein
, zonula occludens protein 1
, tight junction protein 1 (zona occludens 1)
, zonula occludens 1