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Full name:: rho GDP Dissociation Inhibitor (GDI) beta Proteins (ARHGDIB)

On www.antibodies-online.com are 11 rho GDP Dissociation Inhibitor (GDI) beta (ARHGDIB) Proteins from 9 different suppliers available. Additionally we are shipping ARHGDIB Antibodies (146) and ARHGDIB Kits (7) and many more products for this protein. A total of 171 ARHGDIB products are currently listed.

Synonyms:: arhgdib, D4, GDIA2, Gdid4, Ly-GDI, LYGDI, MGC69067, RAP1GN1, rhodgi-2, rhodgi2, RhoGDI2, zgc:65966

list all proteins	Gene Name	GeneID	UniProt
	ARHGDIB	397	P52566
	ARHGDIB	11857	Q61599
Rat ARHGDIB	ARHGDIB	362456
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Human rho GDP Dissociation Inhibitor (GDI) beta (ARHGDIB) interaction partners

RhoGDIbeta overexpression led to downregulation of miR (show MLXIP Proteins)-200c, whereas miR (show MLXIP Proteins)-200c was able directly to target 3'-UTR of jnk2mRNA and attenuated JNK2 (show MAPK9 Proteins) protein translation, which resulted in attenuation of Sp1mRNA and protein expression in turn, inhibiting Sp1 (show PSG1 Proteins)-dependent MMP-2 (show MMP2 Proteins) transcription.
Binders to RhoGDI2 as a potential anti-cancer target have been first reported, and their weak interactions were depicted using NMR spectroscopy.
Together, our results suggest a role for Ly-GDI in the localized regulation of Rho GTPases in platelets and hypothesize a link between the PKC (show PRRT2 Proteins) and Rho GTPase (show RACGAP1 Proteins) signaling systems in platelet function.
Delta19RhoGDIbeta has an apoptosisindependent role in the phorbol 12myristate 13acetate induced differentiation of THP1 cells to macrophages.
The caspase-3 (show CASP3 Proteins)-cleaved RhoGDIbeta is a possible determinant to promote cancer spreading.
Our interpretation of these contradictions is that truncation and/or mutation of RhoGDI2 perturbs its conformation to expose a site that adventitiously binds FLNA (show FLNA Proteins) and is not a bona-fide interaction.
Results show that RhoGDI2 suppresses bladder cancer metastatic colonization via negative regulation of RhoC (show RHOC Proteins) activity, providing a rationale for the development of therapeutics that target RhoC (show RHOC Proteins) signaling.
These findings indicate that RhoGDI2 repressed the activity of Rac1 and may be involved in the rearrangement of cytoskeleton in lung cancer cells.
Short hairpin RNA-mediated knockdown of RhoGDI2 induces the invasion and migration of lung cancer due to cross-talk with the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway and MMP-9 (show MMP9 Proteins).
RhoGDI2 overexpression is associated with tumor growth, metastasis, and chemoresistance in gastric cancer.

Mouse (Murine) rho GDP Dissociation Inhibitor (GDI) beta (ARHGDIB) interaction partners

Ly-GDI is a critical regulator of inflammatory injury after deposition of IgG immune complexes and that it negatively regulates the lung NF-kappaB (show NFKB1 Proteins) activity.
these results indicate that RhoGDIbeta functions as a novel BMP4 (show BMP4 Proteins) signaling target that regulates adipogenesis and myogensis.
Rictor regulates cell migration by suppressing RhoGDI2.
Raptor (show RPTOR Proteins) siRNA suppressed the effects of GM3 (show GRM6 Proteins) on Ly-GDI expression and Akt (show AKT1 Proteins) phosphorylation at Thr (show TRH Proteins)(308) , suggesting GM3 (show GRM6 Proteins) signals to be transduced to mTOR (show FRAP1 Proteins)-Raptor (show RPTOR Proteins) and Akt (show AKT1 Proteins)-Thr (show TRH Proteins)(308) , leading to Ly-GDI stimulation
Impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis.
Rho GDIalpha (show GDI1 Proteins) and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner.

ARHGDIB Protein Profile

Protein Summary

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993

Alternative names and synonyms associated with ARHGDIB

Rho GDP dissociation inhibitor (GDI) gamma (arhgdig)
Rho GDP dissociation inhibitor (GDI) beta S homeolog (arhgdib.S)
Rho GDP dissociation inhibitor beta (ARHGDIB)
Rho GDP dissociation inhibitor (GDI) beta (arhgdib)
Rho, GDP dissociation inhibitor (GDI) beta (Arhgdib)
Rho GDP dissociation inhibitor beta (Arhgdib)

arhgdib protein
D4 protein
GDIA2 protein
Gdid4 protein
Ly-GDI protein
LYGDI protein
MGC69067 protein
RAP1GN1 protein
rhodgi-2 protein
rhodgi2 protein
RhoGDI2 protein
zgc:65966 protein

Protein level used designations for ARHGDIB

rho GDP-dissociation inhibitor 2 , Rho GDP dissociation inhibitor (GDI) beta , D4-GDI , D4-GDP-dissociation inhibitor , ly-GDI , rho GDI 2 , rho-GDI beta , Rho GDI 2

GENE ID	SPECIES
394132	Danio rerio
380352	Xenopus laevis
417941	Gallus gallus
448583	Xenopus (Silurana) tropicalis
702320	Macaca mulatta
742002	Pan troglodytes
100223440	Taeniopygia guttata
327676	Bos taurus
397	Homo sapiens
486666	Canis lupus familiaris
100155466	Sus scrofa
11857	Mus musculus
362456	Rattus norvegicus

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