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Browse our CADM2 Proteins (CADM2)

Full name:: Cell Adhesion Molecule 2 Proteins (CADM2)

On www.antibodies-online.com are 7 Cell Adhesion Molecule 2 (CADM2) Proteins from 3 different suppliers available. Additionally we are shipping CADM2 Antibodies (83) and CADM2 Kits (3) and many more products for this protein. A total of 96 CADM2 products are currently listed.

Synonyms:: 2900078E11Rik, 9330131D06, A830029E02Rik, Igdf4d, igsf4d, Necl-3, NECL3, SynCAM 2, synCAM2, zgc:66339

list all proteins	Gene Name	GeneID	UniProt
	CADM2	239857	Q8BLQ9
	CADM2	360687	Q1WIM2
	CADM2	253559	Q8N3J6
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Relevant Pathways for CADM2 Proteins

Cell-Cell Junction Organization

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Mouse (Murine) Cell Adhesion Molecule 2 (CADM2) interaction partners

Cadm2 expression regulates body weight and glucose homeostasis.

Human Cell Adhesion Molecule 2 (CADM2) interaction partners

Study demonstrated that CADM2 was markedly downregulated in human glioma tissues compared with normal brain tissue and glioma cell lines, and the CADM2 expression level was significantly decreased in highgrade glioma tissues. Overexpression of CADM2 inhibited the proliferation of glioma cell proliferation in vitro and in vivo.
results indicated that CADM2 is a direct target of miR-10b in HCC cells and miR-10b/CADM2 modulates EMT process and migration ability via focal adhesion kinase (FAK) /AKT signaling pathway in HCC.
Results indicated that miR182 expression was increased in retinoblastoma (RB) tissues. When the expression of miR182 was downregulated, cell viability, invasion, tumor volume and angiogenesis were significantly decreased.
Ectopic expression of CADM2 counteracted the promoting effect of miR-146a on cell proliferation, migration, invasion, and the epithelial-mesenchymal transition process.
CADM2 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis]
A significant association was observed for the single-nucleotide polymorphism (SNP) rs17518584 and in the joint discovery and replication meta-analysis in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST.
In the absence of SynCAMs, selective axon-axon interactions are perturbed resulting in aberrant pathfinding of sensory axons.
Cox regression analysis indicated that CADM2 expression level, tumor size, tumor number, vascular invasion, HBsAg were independent risk factors for HCC recurrence
Thus, we conclude that CADM2 functions as a novel tumor suppressor and may serve as a potential therapeutic target for human renal cell carcinoma.
The results indicated that CADM2 is one of the pathogenic factors for psoriasis.
Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers.

Zebrafish Cell Adhesion Molecule 2 (CADM2) interaction partners

Data show that cadm3 and cadm2a are expressed throughout the nervous system of larval stage zebrafish.

CADM2 Protein Profile

Protein Summary

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CADM2

cell adhesion molecule 2 (CADM2)
cell adhesion molecule 2 (Cadm2)
cell adhesion molecule 2a (cadm2a)

2900078E11Rik protein
9330131D06 protein
A830029E02Rik protein
Igdf4d protein
igsf4d protein
Necl-3 protein
NECL3 protein
SynCAM 2 protein
synCAM2 protein
zgc:66339 protein

Protein level used designations for CADM2

cell adhesion molecule 2 , NECL-3 , immunoglobulin superfamily member 4D , immunoglobulin superfamily, member 4 , nectin-like protein 3 , synaptic cell adhesion molecule 2 , immunoglobulin superfamily, member 4D , nectin-like 3 , cell adhesion molecule 2a , immunoglobulin superfamily, member 4d

GENE ID	SPECIES
100069765	Equus caballus
239857	Mus musculus
360687	Rattus norvegicus
719312	Macaca mulatta
253559	Homo sapiens
487680	Canis lupus familiaris
517759	Bos taurus
100734249	Cavia porcellus
793954	Danio rerio
100340168	Oryctolagus cuniculus
418463	Gallus gallus

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