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Cadm2 expression regulates body weight and glucose homeostasis.
Study demonstrated that CADM2 was markedly downregulated in human glioma tissues compared with normal brain tissue and glioma cell lines, and the CADM2 expression level was significantly decreased in highgrade glioma tissues. Overexpression of CADM2 inhibited the proliferation of glioma cell proliferation in vitro and in vivo.
results indicated that CADM2 is a direct target of miR-10b in HCC cells and miR-10b/CADM2 modulates EMT process and migration ability via focal adhesion kinase (FAK) /AKT signaling pathway in HCC.
Results indicated that miR182 expression was increased in retinoblastoma (RB) tissues. When the expression of miR182 was downregulated, cell viability, invasion, tumor volume and angiogenesis were significantly decreased.
Ectopic expression of CADM2 counteracted the promoting effect of miR-146a on cell proliferation, migration, invasion, and the epithelial-mesenchymal transition process.
CADM2 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis]
A significant association was observed for the single-nucleotide polymorphism (SNP) rs17518584 and in the joint discovery and replication meta-analysis in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST.
In the absence of SynCAMs, selective axon-axon interactions are perturbed resulting in aberrant pathfinding of sensory axons.
Cox regression analysis indicated that CADM2 expression level, tumor size, tumor number, vascular invasion, HBsAg were independent risk factors for HCC recurrence
Thus, we conclude that CADM2 functions as a novel tumor suppressor and may serve as a potential therapeutic target for human renal cell carcinoma.
The results indicated that CADM2 is one of the pathogenic factors for psoriasis.
Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers.
Data show that cadm3 and cadm2a are expressed throughout the nervous system of larval stage zebrafish.
This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
cell adhesion molecule 2
, immunoglobulin superfamily member 4D
, immunoglobulin superfamily, member 4
, nectin-like protein 3
, synaptic cell adhesion molecule 2
, immunoglobulin superfamily, member 4D
, nectin-like 3
, cell adhesion molecule 2a
, immunoglobulin superfamily, member 4d