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Data suggest that Nrx-1 plays critical roles in regulating synaptic terminal clustering and release of synaptic vesicles of the neuromuscular junction; Nrx-1 controls terminal clustering and release of synaptic vesicles by stimulating presynaptic actin cytoskeleton assembly; Nrx-1 functions via Scribble and Pixie to activate Rac1. (Nrx-1 = neurexin-1; Rac1 = GTP-binding protein Rac1)
the simultaneous loss of the asymmetric cell division regulators Canoe (afadin in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and canoe loss-mediated Ras-PI3K-Akt (show AKT1 Proteins) activation
the effects of loss of scrib and the modification of these effects via cooperative interactions that enhance the overall tumorigenic potential of scrib deficient cells, is reported.
Knocking down scribble expression in either Mushroom body neurons or Dopaminergic neurons impairs normal memory loss.
Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP (show TGFb Proteins) signaling. Scrib regulates BMP (show TGFb Proteins)-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 (show RAB5A Proteins) endosomes, where Tkv is active
Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo.
Loss of scrib, dlg (show DLG4 Proteins) and lgl had no effect on gonad formation, but Dlg (show DLG4 Proteins) and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.
Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions.
Loss of Scrib promotes Yorkie (show YAP1 Proteins)/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf (show RAF1 Proteins) signaling.
Data show that mutations causing the loss of Salvador (Sav (show SAV1 Proteins)) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules.
Results identify a key planar cell polarity (PCP (show BMP1 Proteins)) protein, Scrib, as one of the fundamental scaffold proteins that enable hippocampal glutamatergic synapses to mature and to express bidirectional plasticity required for memory formation. Study offers a unique insight into the mechanism by which the PCP (show BMP1 Proteins) protein Scrib can regulate memory formation at postnatal stages.
In the Scrib mutant, despite severe neural tube defects, epF (show HSPE1 Proteins) and preBotC neurons settled at their expected hindbrain positions. Furthermore, both networks remained capable of generating rhythmically organized, respiratory-related activities and exhibited normal sensitivity to pharmacological agents known to modify respiratory circuit function.
SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy.
Suggest a role for Plexin-B1 (show PLXNB1 Proteins) as a ligand and Sema4A (show Sema4a Proteins) as a receptor and characterize a reverse signaling pathway downstream of Sema4A (show Sema4a Proteins) regulating cell migration via Scrib.
SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages
we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.
Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1 (show ZGLP1 Proteins).
The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium.
Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA (show COPA Proteins)) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 (show VANGL2 Proteins) and Scribble both prior to and after midline crossing; experiments establish CoPA (show COPA Proteins) axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.
Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation.
Suppression of scrib and puf60 (show PUF60 Proteins) in zebrafish leads to reduction in body length, small head size, and craniofacial defects.
It was found that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways.
Lpp interacts with the PCP (show PRCP Proteins) protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.
Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates
Perturbation of hepatocellular polarity due to overexpression and cytoplasmic enrichment of Scrib supports tumor initiation and hepatocellular carcinoma cell dissemination through specific molecular mechanisms
Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 (show RPS6KA2 Proteins) and MCC (show MCC Proteins) were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 (show RPS6KA2 Proteins) = ribosomal protein S6 kinase 2 (show RPS6KA3 Proteins); MCC (show MCC Proteins) = mutated in colorectal cancer protein)
Scrib inhibits liver cancer cell proliferation by suppressing the expression of three oncogenes, Yap1 (show YAP1 Proteins), c-Myc (show MYC Proteins) and cyclin D1 (show CCND1 Proteins), thereby functioning as a tumor suppressor in liver cancer.
In this study the authors show that human Scrib expression is required for maintaining high levels of human papillomavirus type 18 E6 protein in HeLa cells.
Data suggest that Scribble PDZ-domain-1 and PDZ-domain-3 are major domains that interact with beta-PIX (show ARHGEF7 Proteins) and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ domains and beta-PIX (show ARHGEF7 Proteins). (Scribble = scribbled planar cell polarity protein; beta-PIX (show ARHGEF7 Proteins) = Rho guanine nucleotide exchange factor 7 (show ARHGEF7 Proteins))
inhibiting acyl thioesterase (show FASN Proteins) 2 restores balance to the Scrib palmitoylation cycle, promoting membrane re-localization and growth attenuation
sequencing analysis of SCRIB1 in 473 NTD patients led to the identification of 5 rare heterozygous missense mutations that were predicted to be pathogenic. Two of these mutations, p.Gly263Ser and p.Gln808His, and 2 mouse NTD mutations, p.Ile285Lys and p.Glu814Gly, affected Scrib1 membrane localization and its modulating role of Par-3 (show F2RL2 Proteins) and Vangl1 (show Vangl1 Proteins) localization.
a new function for Scribble in Rho regulation that entails positioning of DLC3 (show STARD8 Proteins) GAP activity at cell junctions in polarized epithelial cells, is reported.
Low Scribble expression in the primary breast tumor was correlated to prognosis in estrogen receptor (show ESR1 Proteins)-positive breast cancer patients.
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, immune response deficient 15
, lethal (3) c00119
, smell impaired 97B
, PDZ-domain protein scribble
, protein scribble homolog
, scribble homolog 1
, scribbled homolog