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Promoter elements of positive and negative transcriptional control were identified.
Strong ERK activation can target Cdc25A for degradation in a manner similar to, but independent of, Chk1 for cell cycle arrest.
Study findings identify beta-TrCP as an important negative regulator for upstream signaling of IkappaBalpha in lipopolysaccharide pathway, and therefore renew the understanding of the roles of beta-TrCP in regulating toll-like receptors inflammatory signaling.
Beta transducin repeat-containing protein (beta-TrCP1) interacts with PERIOD2 (PER2) through conserved phosphoswitches i.e. SEP480 and SEP484 residues.
findings reveal that Akt activity determines the phosphorylation status of TBC1D7 at the phospho-switch Ser-124, which governs binding to either 14-3-3 or beta-TrCP2, resulting in increased or decreased stability of TBC1D7, respectively.
Study found that the F-box protein bTrCP binds a DSGmotif located within the N-terminus of STIL, and that mutation of this degron leads to STIL stabilization and consequent centriole overduplication.
Reciprocal regulation between betaTrCP and Smurf1 has been found to inhibit proliferative capacity of liver cancer cells.
a phosphorylation mutant form of Mxi1 (Mxi1-S160A), which cannot be degraded by S6K1 and beta-Trcp, is much more stable and efficient in suppressing the transcriptional activity of Myc and radioresistance in lung cancer cells.
beta-TrCP was identified as a novel interacting partner of ASK1 that is capable of ubiquitinating and degrading ASK1 through the ubiquitin-proteasome system. These findings suggest that beta-TrCP is capable of suppressing oxidative stress-induced caspase 3-dependent apoptosis through suppression of ASK1.
The primary role of the S(52,56) residues of Vpu in antagonism of CD4, GaLV Env, and BST-2/tetherin is to recruit the SCF/betaTrCP ubiquitin ligase.
TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-kappaB signaling.
BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation.
Data show that the SCF(beta-TrCP) ubiquitin E3 ligase complex responsible for regulating the active protein kinase C-associated kinase (RIPK4) level.
SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S ubiquitin-conjugating enzymes to ubiquitylate beta-TrCP1 via K11-linkage for degradation.
Data indicate the role of tyrosine kinase c-Src (Src) in rescuing Taz (transcriptional coactivator with PDZ-binding motif) from E3 ligase SCF(beta-TrCP)-mediated degradation.
SCFbeta-TRCP negatively regulates the FLCN complex by promoting FNIP2 degradation in Birt-Hogg-Dube syndrome-associated renal cancer.
beta-TRCP depletion in HepG2 hepatocellular carcinoma cells resulted in increased Lipin1 protein abundance.
It demonstrates that degradation of Lipin-1 is regulated by BTRC in the cytoplasm and on membranes
we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.
It has been proposed that CENP-W may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.
oncogenic effect of miR-182 and its reversal by beta-TrCP2 were confirmed in vivo This study suggests that beta-TrCP and miR-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H.
Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm.
beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation.
Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 stability.
betaTrCP levels are correlated with imiquimod-induced skin lesion.
beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth
Erbin as a novel substrate of SAG-betaTrCP E3 ligase.
these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis.
beta-TrCP may be an essential player in UVB induced responses in skin
Glycogen synthase kinase 3 phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1-independent manner.
LPS appears to destabilize the LPCAT1 protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.
the two beta-TrCP paralogs have a nonredundant role in spermatogenesis
anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF(beta-TrCP)
BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts
Results suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types.
hnRNP-U engages a highly neddylated active SCF beta-TrCP which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter.
HOS plays a role in inhibiting cell differentiation and cell transformation
b-TrCP controls meiotic and mitotic progression in vivo.
beta-TrCP1 contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
beta-transducin repeat containing
, beta-transducin repeat containing protein
, F-box/WD repeat-containing protein 1A
, f-box/WD repeat-containing protein 1A-like
, F-box and WD repeats protein beta-TrCP
, F-box and WD-repeat protein 1B
, epididymis tissue protein Li 2a
, pIkappaBalpha-E3 receptor subunit
, beta-transducin repeat-containing protein
, SCF b-TRCP
, beta-TrCP protein E3RS-IkappaB
, pIkappaB-E3 receptor subunit
, ubiquitin ligase FWD1