Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Alternative names and synonyms associated with BTRC

• beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) antibody
• beta-transducin repeat containing E3 ubiquitin protein ligase (btrc) antibody
• beta-transducin repeat containing (btrc) antibody
• beta-TrCP (LOC100634006) antibody
• beta-transducin repeat containing E3 ubiquitin protein ligase (Btrc) antibody
• Show all gene names
• beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog (btrc.S) antibody
• beta-transducin repeat containing protein (Btrc) antibody

• b-TrCP antibody
• BETA-TRCP antibody
• Beta-Trcp1 antibody
• betaTrCP antibody
• btrc antibody
• Show all synonym aliases
• btrc-a antibody
• bTrCP antibody
• bTrCP1 antibody
• Fbw1a antibody
• FBXW1 antibody
• FBXW1A antibody
• FWD1 antibody
• HOS antibody
• mKIAA4123 antibody
• Slimb antibody

Protein level used designations for BTRC

beta-transducin repeat containing , beta-transducin repeat containing protein , F-box/WD repeat-containing protein 1A , f-box/WD repeat-containing protein 1A-like , E3RSIkappaB , F-box and WD repeats protein beta-TrCP , F-box and WD-repeat protein 1B , beta-TrCP1 , epididymis tissue protein Li 2a , pIkappaBalpha-E3 receptor subunit , beta-TrCP , beta-transducin repeat-containing protein , SCF b-TRCP , beta-TrCP protein E3RS-IkappaB , mE3RS-IkappaB , pIkappaB-E3 receptor subunit , ubiquitin ligase FWD1