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These results suggest that miR (show MLXIP Proteins)-125a-3p can function as a novel tumor suppressor in ER(+) breast cancer by targeting CDK3, which may be a potential therapeutic approach for TamR breast cancer therapy
HuR (show ELAVL1 Proteins) facilitated lung cancer stemness dependent on CDK3 expression. miR (show MLXIP Proteins)-873 or miR (show MLXIP Proteins)-125a-3p level was negatively correlated with HuR (show ELAVL1 Proteins) and CDK3 expression levels in lung cancer tissues. HuR (show ELAVL1 Proteins) facilitates lung cancer stemness via regulating miR (show MLXIP Proteins)-873/CDK3 and miR (show MLXIP Proteins)-125a-3p/CDK3 axis.
ectopic expression of HuR (show ELAVL1 Proteins) promotes breast cancer cell proliferation and survival by directly binding to and stabilizing CDK3 mRNA.
These results provided evidence supporting the oncogenic potential of NFAT3 (show NFATC4 Proteins) and suggested that CDK3-mediated phosphorylation of NFAT3 (show NFATC4 Proteins) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (show MLXIP Proteins)-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR (show MLXIP Proteins)-150 transfection experiments with cancer-derived cell lines reveal that miR (show MLXIP Proteins)-150-mediated CDK3 suppression directly induces growth inhibition.
High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (show FOSB Proteins) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (show MLXIP Proteins)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A Proteins)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 Proteins)), cyclin (show PCNA Proteins)-dependent kinases CDK3 and CDK6 (show CDK6 Proteins).
Mir (show MLXIP Proteins)-873 inhibits ESR1 (show ESR1 Proteins) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (show NPC1 Proteins), and may be a potential biomarker for prediction of the prognosis of patients with NPC (show NPC1 Proteins).
The Walleye dermal sarcoma virus cyclin (show PCNA Proteins) functions as a structural ortholog of cyclin C (show CCNC Proteins) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (show CDK8 Proteins) and Cdk3.
Results indicated that CDKL3 (show CDKL3 Proteins) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (show CDKL3 Proteins) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cell division protein kinase 3
, cyclin-dependent kinase 3