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This study reveals a molecular pathway involving lncRNA GAS5/E2F1 (show E2F1 Proteins)/P27(Kip1) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.
miR (show MLXIP Proteins)-155-5p promotes fibroblast cell proliferation and inhibits FOXO (show FOXO3 Proteins) signaling pathway by negative modulation of both FOXO3 (show FOXO3 Proteins) and CDKN1B in vulvar lichen sclerosis
We demonstrate that E6AP (show ube3a Proteins) regulates p27 (show PAK2 Proteins) expression by inhibiting its transcription in an E2F1 (show E2F1 Proteins)-dependent manner. Concomitant knockdown of E6AP (show ube3a Proteins) and p27 (show PAK2 Proteins) partially restores PC cell growth, supporting the contribution of p27 (show PAK2 Proteins) to the overall effect of E6AP (show ube3a Proteins) on prostate tumorigenesis.
The results presented herein highlight the importance of p21Cip1 (show CDKN1A Proteins) and p27Kip1 in the cell cycle control and drug resistance of glioma stem cells, providing new insights into the field of glioma biology.
LncRNA-ANCR (show ube3a Proteins) inhibited the cell proliferation, migration, and invasion of osteosarcoma cells, possibly through interacting with EZH2 (show EZH2 Proteins) and regulating the expression of p21 (show CDKN1A Proteins) and p27 (show PAK2 Proteins).
SIRT1 (show SIRT1 Proteins)-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells
we suggest that gastrin (show GAST Proteins) contributes to the emergence of MDR of SGC7901 cells via the degradation of p27Kip1
this studies show that p27kip1 is an important regulator of Ras induced neoplastic transformation
upregulation of p21Cip1 (show CDKN1A Proteins) and p27Kip1 contributes to the synergistic anticancer effect of the halofuginone-artemisinin combination
Loss of p27kip1 expression is frequently found in papillary thyroid carcinoma (PTC (show F9 Proteins)) compared with benign lesions and normal thyroid tissue. When present in PTC (show F9 Proteins), it is correlated with aggressive tumor behavior.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
FoxO1a (show FOXO1 Proteins) can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA (show RHOA Proteins) signaling.
Specifically, the proteins p18INK4C (show CDKN2C Proteins), p21CIP1 (show CDKN1A Proteins) and p27KIP1 seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.
Data show that both bone marrow-derived and gastric epithelial cells contribute to the increased gastric cancer susceptibility of p27-deficient Helicobacter pylori (H. pylori) -infected mice.
Our results revealed that CKS1 (show CKS1B Proteins) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.
p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.
This study demonstrates that LMP2A uses the role of MYC (show MYC Proteins) in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 (show PITX2 Proteins) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 (show PITX2 Proteins) causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (show PITX2 Proteins) and p21.
Fbxo7 (show FBXO7 Proteins)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (show CDK6 Proteins) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Proteins) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F (show E2F1 Proteins) and p27-CDK (show CDK4 Proteins) regulation, is reported.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
cyclin-dependent kinase inhibitor 1B
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27
, Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27/Kip1
, Cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor 1b, like