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A-MYB regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachytene piRNAs during early meiosis in mouse testes.
A-MYB (MYBL1) stimulates murine testis-specific (show AIF1 Proteins) Ldhc (show LDHC Proteins) expression via the cAMP-responsive element (CRE) site.
Results reveal that MYBL1 is a master regulator of meiotic genes that are involved in multiple processes in spermatocytes, particularly those required for cell cycle progression through pachynema.
RFX2 (show RFX2 Proteins) is potentially an important transcriptional regulator in pachytene spermatocytes; Rfx2 (show RFX2 Proteins) itself is a good candidate to be regulated by A-MYB, which is essential for meiotic progression.
A-myb plays a role in the reactive gliosis signaling pathway in kainic acid-induced excitotoxic lesions
Low MYBL1 expression is associated with colon cancer.
Our study defines new molecular subclasses of ACC characterized by MYBL1 rearrangements and 5'-NFIB (show NFIB Proteins) gene fusions.
Thus, the LIMD1 (show LIMD1 Proteins)-MYBL1 Index had considerable clinical value for DLBCL subtype classification and prognosis.
analysis of genetic alterations in MYBL1 in diffuse pediatric low-grade gliomas
Strong transcriptional activator\; DNA-binding protein that specifically recognize the sequence 5'-YAACG-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
myb-like protein 1
, myb-related protein A
, MYB-related protein 2
, v-myb myeloblastosis viral oncogene homolog-like 1
, myeloblastosis oncogene-like 1