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A-MYB regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachytene piRNAs during early meiosis in mouse testes.
A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site.
Results reveal that MYBL1 is a master regulator of meiotic genes that are involved in multiple processes in spermatocytes, particularly those required for cell cycle progression through pachynema.
RFX2 is potentially an important transcriptional regulator in pachytene spermatocytes; Rfx2 itself is a good candidate to be regulated by A-MYB, which is essential for meiotic progression.
A-myb plays a role in the reactive gliosis signaling pathway in kainic acid-induced excitotoxic lesions
Breast adenoid cystic carcinomas probably constitute a convergent phenotype, whereby activation of MYB and MYBL1 and their downstream targets can be driven by the MYB-NFIB fusion gene, MYBL1 rearrangements, MYB amplification, or other yet to be identified mechanisms.
In the present study, MYB or MYBL1 locus rearrangement was detected in nearly all adenoid cystic carcinoma cases, and therefore it would be a good diagnostic marker for adenoid cystic carcinoma.
MYBL1 alterations are detected in primary cutaneous adenoid cystic carcinoma but are apparently less common compared with MYB and NFIB alterations.
Low MYBL1 expression is associated with colon cancer.
Our study defines new molecular subclasses of ACC characterized by MYBL1 rearrangements and 5'-NFIB gene fusions.
Thus, the LIMD1-MYBL1 Index had considerable clinical value for DLBCL subtype classification and prognosis.
analysis of genetic alterations in MYBL1 in diffuse pediatric low-grade gliomas
Strong transcriptional activator\; DNA-binding protein that specifically recognize the sequence 5'-YAACG-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
myb-like protein 1
, myb-related protein A
, MYB-related protein 2
, v-myb myeloblastosis viral oncogene homolog-like 1
, myeloblastosis oncogene-like 1