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Data indicate that nuclear envelope rupture in cancer cells is likely due to loss of either the Rb or the p53 (show TP53 Proteins) pathway.
Altered pRb is frequently expressed in gastric carcinoma, inversely correlates with tumor invasion and tumor stage suggesting an early event in gastric carcinogenesis.
results define a network of E2F (show E2F1 Proteins) target genes as susceptible to the regulatory influence of H1.2 (show HIST1H1C Proteins), where H1.2 (show HIST1H1C Proteins) augments global association of pRb with chromatin, enhances transcriptional repression by pRb, and facilitates pRb-dependent cell-cycle arrest
The increased expression of miR-503-5p significantly reduced the expressions of E2F transcription factor 3 (E2F3) mRNA and retinoblastoma protein (Rb)/E2F signaling pathway mRNA in bladder cancer cells.
Loss of Rb immunolabeling and KRAS mutation are promising molecular markers of the therapeutic response to platinum-based chemotherapy for pancreatic neuroendocrine neoplasm grade-3 (PanNEN-G3), and Rb for neuroendocrine tumor with G3 (NET-G3).
We recommend intensive ocular screening for patients with germline RB1 mutations for retinoblastoma as well as neuroimaging for pineoblastoma surveillance. There is an approximately 20% risk of developing second primary cancers among individuals with hereditary RB, higher among those who received radiotherapy for their primary RB tumors
miR (show MLXIP Proteins)-215 promoted cell migration and invasion of gastric cancer by directly targeting RB1.
MiR (show MLXIP Proteins)-661 promotes metastasis of non small cell lung cancer through RB/E2F1 (show E2F1 Proteins) signaling and epithelial-mesenchymal transition events.
RB1 was identified as a direct and functional target of miR (show MLXIP Proteins)-215. RB1 is generally down-regulated in glioma tissues and its expression inversely correlated with miR (show MLXIP Proteins)-215, which is up-regulated in high-grade glioma tissues, and its expression was negatively correlated with miR (show MLXIP Proteins)-215.
Results show that RB1 expression is regulated by cdc37 (show CDC37 Proteins) which facilitates its phosphorylation through increasing CDK4 (show CDK4 Proteins) stability.
Thus, Lin37 (show LIN37 Proteins) is an essential component of DREAM complex that cooperates with Rb to induce quiescence.
Results show that ablation of the three members of the retinoblastoma family (RB1, p107 (show RBL1 Proteins) and p130) which targets a variety of adult lung epithelial cells, leads to spontaneous velopment of tumorlets, benign precancerous neuroendocrine (NE) lesions that do not progress to malignant tumors. Data imply the requirement of other oncogenic signaling pathways for full transformation in NE lung lesions mutant for the Rb family.
NFIB (show NFIB Proteins) overexpression interacts with Rb/p53 (show TP53 Proteins) deletion to promote small cell lung cancer in a mouse model
studies demonstrate that pRb (show PGR Proteins) loss in the Tie2 (show TEK Proteins)-lineage that includes aortic valve interstitial cells is sufficient to cause age-dependent aortic valve dysfunction
Cytokeratin-19 (CK-19 (show KRT19 Proteins))+ specific deletion of tumor suppressors p53 (show TP53 Proteins) and Retinoblastoma (Rb) indicated that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells.
Rb selectively inhibits innate IFN-beta (show IFNB1 Proteins) production by enhancing deacetylation of Ifnb1 (show IFNB1 Proteins) promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (show RBL1 Proteins), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 (show SOCS3 Proteins) protein (Socs3 (show SOCS3 Proteins)) expression in triple knockout (TKO (show MRPS12 Proteins)) HSCs.
Combined deletion of Vhl (show VHL Proteins), Trp53 (show TP53 Proteins) and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (show MOK Proteins).
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (show E2F1 Proteins) to recruit EZH2 (show EZH2 Proteins) to diverse repeat sequences.
data indicate that the Rb1-E2F1 (show E2F1 Proteins)-caspase (show CASP3 Proteins) axis is crucial for protecting immature T cells from apoptosis during early T lymphocyte maturation.
Our results indicate that Rb-Raf-1 (show RAF1 Proteins) interaction plays an important role in spontaneous hair cell regeneration in zebrafish
our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.
Zebrafish usp39 (show USP37 Proteins) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (show E2F4 Proteins) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
retinoblastoma suspectibility protein
, retinoblastoma-associated protein
, RNA-binding motif protein 45
, RNA-binding protein 45
, developmentally regulated RNA-binding protein 1
, developmentally-regulated RNA-binding protein 1
, putative RNA binding protein RB-1
, Retinoblastoma 1 (including osteosarcoma)
, retinoblastoma 1 (including osteosarcoma)
, retinoblastoma protein
, retinoblastoma, susceptibility
, Retinoblastoma-associated protein
, retinoblastoma 1
, retinoblastoma-associated protein-like