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Authors show that MYC (show MYC Proteins) inhibition by Omomyc, a dominant-negative MYC (show MYC Proteins), suppresses the growth of SCLC cells with TP53 (show TP53 Proteins) and RB1 inactivation carrying MYC (show MYC Proteins), MYCL, or MYCN (show MYCN Proteins) amplification.
Data suggest that the platelet derived growth factor receptor alpha (show PDGFRA Proteins) (PDGFRalpha)/Stat3 (show STAT3 Proteins) transcription factor/Rb1 protein regulatory axis might represent a potential therapeutic target for glioblastoma (GBM) treatment.
miR (show MLXIP Proteins)-590 inhibits RB1 and promotes proliferation and invasion of T-cell acute lymphoblastic leukaemia cells
causative RB1 mutations in most bilateral retinoblastoma (RB) patients and in some unilateral RB patients, including five novel mutations, were identified.
homozygous loss of RB1 is an independent prognostic marker in multiple myeloma
In certain contexts, Rb loss enables TRbeta1 (show THRB Proteins)-dependent suppression of SKP2 as a safeguard against RB1-deficient tumorigenesis. TRbeta2 counteracts TRbeta1 (show THRB Proteins), thus disrupting this safeguard and promoting development of RB1-deficient malignancies.
Expression levels of miR (show MLXIP Proteins)-675-5p in glioma tissues and cells were negatively correlated with RB1 expression at both mRNA and protein levels and promoted cell proliferation and migration.
Disruption of DREAM and RB-E2F (show E2F1 Proteins) complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53 (show TP53 Proteins)-mediated downregulation of cell cycle genes. [review]
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 (show TRIB1 Proteins) and TRb2 (show TRIB2 Proteins)-mediated PTTG1 (show PTTG1 Proteins) inhibition, counteracting Rb-deficiency-related genomic instability.
APC (show APC Proteins)/C and pRB interact with each other via the co-activator of APC (show APC Proteins)/C, FZR1 (show FZR1 Proteins), providing an alternative pathway of regulation of G1 to S transition by pRB using a post-translational mechanism. Both pRB and FZR1 (show FZR1 Proteins) have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism.
Rb selectively inhibits innate IFN-beta (show IFNB1 Proteins) production by enhancing deacetylation of Ifnb1 (show IFNB1 Proteins) promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (show RBL1 Proteins), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 (show SOCS3 Proteins) protein (Socs3 (show SOCS3 Proteins)) expression in triple knockout (TKO (show MRPS12 Proteins)) HSCs.
Combined deletion of Vhl (show VHL Proteins), Trp53 (show TP53 Proteins) and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (show MOK Proteins).
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (show E2F1 Proteins) to recruit EZH2 (show EZH2 Proteins) to diverse repeat sequences.
The N-Terminal phosphorylation of RB by p38 (show CRK Proteins) bypasses its inactivation by cyclin (show PCNA Proteins)-dependent kinases and prevents proliferation in cancer cells.
SUMO1 (show SUMO1 Proteins) conjugation of RB and Lamin A/C (show LMNA Proteins) is modulated by the SUMO protease SENP1 (show SENP1 Proteins) and that sumoylation of both proteins is required for their interaction.
Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (show CDK4 Proteins) inhibitors releases Rb-mediated mTORC2 (show CRTC2 Proteins) suppression. This, in turn, leads to elevated Akt (show AKT1 Proteins) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (show AKT1 Proteins) inhibitors.
The data presented here support a hypothesis in which RB1 and TP53 (show TP53 Proteins) loss in prostate cancer derepresses Ezh2 (show EZH2 Proteins) and Sox2 (show SOX2 Proteins) factors, creating a stem cell-like epigenetic environment permissive for lineage plasticity
systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F (show E2F1 Proteins) and p27 (show CDKN1B Proteins)-CDK (show CDK4 Proteins) regulation, is reported.
Our results indicate that Rb-Raf-1 (show RAF1 Proteins) interaction plays an important role in spontaneous hair cell regeneration in zebrafish
our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.
Zebrafish usp39 (show USP37 Proteins) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (show E2F4 Proteins) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
retinoblastoma suspectibility protein
, retinoblastoma-associated protein
, RNA-binding motif protein 45
, RNA-binding protein 45
, developmentally regulated RNA-binding protein 1
, developmentally-regulated RNA-binding protein 1
, putative RNA binding protein RB-1
, retinoblastoma-like protein 1
, Retinoblastoma 1 (including osteosarcoma)
, retinoblastoma 1 (including osteosarcoma)
, retinoblastoma protein
, retinoblastoma, susceptibility
, Retinoblastoma-associated protein
, retinoblastoma 1
, retinoblastoma-associated protein-like