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CUX1 is enriched at sites of DNA looping, as determined by Hi-C analysis, and these loops connect CUX1 to the promoters of regulated genes.
our results have uncovered the requirement for CUX1 expression in cancer cells with elevated reactive oxygen species levels
Therefore, we show for the first time that the nuclear localization of Cat L and its substrate Cux1can be positively regulated by Snail NLS and importin beta1, suggesting that Snail, Cat L and Cux1 all utilize importin beta1 for nuclear import.
a positive feedback loop between Snail (show SNAI1 Proteins)-nuclear Cat L (show TRPV6 Proteins)-CUX1 drives epithelial mesenchymal transition, is reprted.
Study found are higher CUTL1 expression level in non-small cell lung cancer (NSCLC) tissues and showed that CUTL1 induced epithelial-mesenchymal transition in NSCLC.
Results show that Cux1 is expressed in cerebellar granule cell precursors and downregulated as they terminally differentiate; coexpression analysis in human medulloblastomas suggests another function related to DNA integrity and stability
High CUX1 expression is associated with metastasis in pancreatic neuroendocrine neoplasms.
Authors identified CUX1 as an important modulator of the TAMs phenotype and function by modulating NF-kappaB (show NFKB1 Proteins)-dependent cytokines.
CASP is specifically cleaved by granzymeB.
Suggest that CUTL1 may regulate the proliferation of malignant melanoma by modulating the expression of cell cycle-related proteins.
reduction of VAV2 in absence of CUX1 was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 regulates normal intestinal epithelial cell restitution
Cux1 expression in polycystic kidney disease is not directly involved in cystogenesis but promotes cell proliferation required for expansion of existing cysts, primarily by repression of p27 (show CDKN1B Proteins).
Cux1 is essential for the developmental modulation of intrinsic excitability and the switch to a Kv1 (show KCNA5 Proteins)-dependent firing mode necessary for interhemispheric innervation.
Findings reinforce the link between oxidative DNA damage and cellular senescence and suggest that the role of CUX1 as an accessory factor in DNA repair will be critical in physiological situations that generate higher levels of reactive oxygen species.
Results suggest that by their differential effects on basal and apical dendrites, Cux1 and Cux2 (show CUX2 Proteins) can promote the integration of layer II-III neurons in the intracortical networks in highly specific ways
Results show that Cux1 is expressed in cerebellar granule cell precursors and downregulated as they terminally differentiate; suggests some limitations of established medulloblastoma cell lines and mouse models
CUX1 functions in base excision repair as an ancillary factor for the 8-oxoG-DNA glycosylase, OGG1 (show OGG1 Proteins).
overexpression of active CUTL1 significantly resulted in increased cancer tissue response to chemotherapy and therefore inhibited growth, whereas knockdown of CUTL1 conferred resistance to chemotherapy.
CUX1, a direct target of microRNA122, is a common central mediator of two effects of microRNA122 disregulation; alpha-fetoprotein (show AFP Proteins) upregulation and an aggressive phenotype in hepatocellular carcinoma.
Increased Cux1 expression associated with apoptosis is a common feature of late stage cyst progression in both the cpk and Pkd1 (show PKD1 Proteins)(CD) mouse models of polycystic kidney disease.
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.
CCAAT displacement protein
, cut homolog
, golgi integral membrane protein 6
, homeobox protein cux-1
, protein CASP
, putative protein product of Nbla10317
, cut-like homeobox 1
, (clone C8) CASP
, cut-like 1, CCAAT displacement protein
, homeobox protein cut-like 1-like
, Cux/CDP homeoprotein
, cut-like 1
, homeobox protein cut-like 1