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anti-Fruit Fly (Drosophila melanogaster) FOXO Antibodies:
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This study implicates FOXO factors, the evolutionarily conserved determinants of animal longevity, in the mechanisms of nutritional programming of animal lifespan.
this study shows that intestinal FoxO signaling is required to survive oral infection in Drosophila
Here, the authors show that cell autonomous insulin (show INS Antibodies) signaling within the Drosophila CM9 motor neuron regulates the release of neurotransmitter via alteration of the synaptic vesicle fusion machinery. This effect of insulin (show INS Antibodies) utilizes the FOXO-dependent regulation of the thor (show EIF4EBP1 Antibodies) gene, which encodes the Drosophila homologue of the eif-4e binding protein (4eBP (show EIF4EBP1 Antibodies)).
This study highlights D. melanogaster as a model of cardiac aging and FOXO as a tightly regulated mediator of proteostasis and heart performance over time.
elevated expression of Pav-KLP (show KIF1B Antibodies) underlies transport and plasticity phenotypes in pathway mutants, indicating that Toll (show TLR4 Antibodies)-6-FoxO signaling promotes MT dynamics by limiting Pav-KLP (show KIF1B Antibodies) expression.
FoxO regulates dendrite structure and function and FoxO-mediated pathways control microtubule dynamics and polarity.
identify the regions of the Hsp70 promoter essential for FOXO-dependent transcription using in vitro methods and find a physiological role for FOXO-dependent expression of heat shock proteins in vivo.
a previously unknown role of dFoxO in promoting Wg signaling, and that a dFoxO-Arm complex is likely involved in their mutual functions, e.g. cell death.
subtle manipulation of foxo through Akt1 (show AKT1 Antibodies) can enhance survival during adverse nutrient conditions in Drosophila.
Inhibition of the mitochondrial TRAP1 (show TRAP1 Antibodies) generates a retrograde cell protective signal from mitochondria to the nucleus in a FOXO-dependent manner.
Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults\; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.
, forkhead Box O
, forkhead bOX-containing protein, subfamily O
, forkhead box
, forkhead box sub-group O
, forkhead box type O
, forkhead box, subgroup O
, forkhead transcription factor