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Single Nucleotide Polymorphism in ABCA1 gene is associated with dyslipidemia.
Increased expression of hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients.
Review/Meta-analysis: significant association of ABCA1 rs2230806 GG with increased risk of ischemic stroke.
Results showed that ABCA1 participates in the alpha-synuclein transport of cholesterol through the plasma membrane of neuronal cells.
HECTD1 (show HECTD1 Proteins) may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I (show APOA1 Proteins).
ABCA1 R219K RR+RK genotype frequency in Alzheimer and Parkinson Disease patients was lower than that in normal controls (NC), while ABCA1 R219K KK genotype frequency was significantly higher. ABCA1 R219K R allele was the risk factor inducing abnormal serum levels of ApoA2 (show APOA2 Proteins), LDL, and TG in AD patients, and abnormal levels of serum ABCA1, HDL (show HSD11B1 Proteins), IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins), and TNF-alpha (show TNF Proteins) in PD patients.
This study provides evidence that, in HepG2 cells, GLP-1 (show GCG Proteins) may affect cholesterol homeostasis by regulating the expression of miR (show MLXIP Proteins)-758 and ABCA1.
Hsp27 may up-regulate the expression of ABCA1 and promotes cholesterol efflux through activation of the PI3K/PKCzeta/Sp1 signal pathway in THP-1 macrophage-derived foam cells
the present study revealed that overexpression of GLP1R (show GLP1R Proteins) significantly reduces proliferation, migration and cytokine release in ASM (show SMPD1 Proteins) cells from COPD (show ARCN1 Proteins) patients; this involved a significant increase in ABCA1 expression levels. This provided evidence to suggest that GLP1R (show GLP1R Proteins) may be a potential therapeutic target for the treatment of COPD (show ARCN1 Proteins).
Abnormal expression of ABCA1 may be associated with the dysregulation of placental lipid metabolism and the occurrence or development of spontaneous deliveries.
our results highlight the importance of the LXR (show NR1H3 Proteins)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Proteins) or ABCG1 (show ABCG1 Proteins) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Proteins) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
TMP upregulated the protein stability of ABCA1 without affecting ABCG1 (show ABCG1 Proteins). Accordingly, TMP regulated the expression of SR-A (show MSR1 Proteins), CD36 (show CD36 Proteins), ABCA1 and ABCG1 (show ABCG1 Proteins) in aortas of ApoE (show APOE Proteins)-/- mice, which resembled the findings observed in macrophages.
HDL3, by interacting with ABCA1, modulates the miR143/145-myocardin axis and prevents the cholesterol-induced gene expression modification in smooth muscle cells regardless of its cholesterol unloading capacity.
(1) ABCA1 maintains optimal hepatocyte PM FC, through intracellular FC trafficking, for efficient insulin (show INS Proteins) signaling; and (2) hepatocyte ABCA1 deletion produces a form of selective insulin (show INS Proteins) resistance so that lipogenesis is suppressed but glucose metabolism remains normal
demonstrates behavior deficits caused by Abca1 deletion in APP (show APP Proteins)/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus.
Rutaecarpine was identified to be a candidate that protected ApoE (show APOE Proteins)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (show SCARB1 Proteins) within RCT (show FOXE3 Proteins).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (show CAV1 Proteins) enhances internalization and degradation of ABCA1 by its association with ABCA1
ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (show APOA1 Proteins) and lipids metabolically segregate.
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1