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Human CCL5 Protein expressed in Human Cells - ABIN2003576
Maghazachi, Al-Aoukaty, Schall: CC chemokines induce the generation of killer cells from CD56+ cells. in European journal of immunology 1996
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CSF levels of RANTES were remarkably h (show TYMS Proteins)igh only in active multiple sclerosis patients. RANTES levels were associated with tr (show SCP2 Proteins)anscranial magnetic stimulation measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity.
we document for the first time that CCL5 induces tumor lymphangiogenesis by the induction of VEGF-C (show VEGFC Proteins) in human cancer cells
Our findings indicate that the -403 G/A RANTES (CCL5) promoter gene polymorphism is connected with psoriasis vulgaris disease severity.
Baseline serum CCL5 levels and decrease of the serum VEGF-A (show VEGFA Proteins) levels may serve as potential predictive markers for survival or treatment-specific toxicities in metastatic colorectal cancer patients receiving regorafenib.
This meta-analysis suggests that RANTES -403G/A and -28C/G polymorphisms confer possible protection against HIV-1 infection, whereas In1.1T/C polymorphism may increase risk of HIV-1 infection, especially in Asians.
CCL5 and CXCL11 (show CXCL11 Proteins) expression were also induced in response to the activation of the PKC (show PRRT2 Proteins) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (show RIPK4 Proteins) and IRF6 (show IRF6 Proteins). Moreover, gene reporter assays suggested that RIPK4 (show RIPK4 Proteins) induces CCL5 and CXCL11 (show CXCL11 Proteins) expression by stimulating the transactivation of their promoters by IRF6 (show IRF6 Proteins).
Data suggest that inhibition of CCL5 in adipose microenvironment may represent an approach for the therapy of highly malignant Triple Negative Breast Cancer (TNBC).
RNA-binding protein (show PTBP1 Proteins) HuR (HuR (show ELAVL1 Proteins)) expression negatively correlated with chemokine (CC motif) ligand 5 (CCL5) expression and macrophage appearance in a cohort of breast tumors.
we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5, HPGDS (show HPGDS Proteins), and NPSR1 (show NPSR1 Proteins)) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS (show HPGDS Proteins) and NPSR1 (show NPSR1 Proteins) in plasma.
Data provide evidence that CCL5 enhances the proliferation and the invasive capacity of human breast cancer cell lines mediated by CCR5 activation.
RANTES levels were associated with TMS (show PYCARD Proteins) measures of cortical synaptic excitability, but not with long-term potentiation (LTP (show SCP2 Proteins))-like plasticity.
study found that the inflammatory chemokine (show CCL1 Proteins) CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (show TBCE Proteins)-expressed D6.
A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis.
CCL5 paradoxically limits macrophage accumulation in the injured kidney during renin (show REN Proteins) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2 (show CCL2 Proteins).
This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.
IL-6 (show IL6 Proteins) Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2 (show CCL2 Proteins)/CCL5 in Non-small Cell Lung Cancer
Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP (show PTPN2 Proteins)-intoxicated mice.
CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis.
RANTES produced by renal tubular cells act as a key chemokine (show CCL1 Proteins) in acute kidney injury and HIF-1alpha (show HIF1A Proteins) regulated LncRNA-PRINS might be involved in RANTES production.
Mycobacterium chelonae activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2 (show CCL2 Proteins)) and CCL5 in murine bone marrow-derived macrophages and in vivo mouse model.
These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.
we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription
The Toll (show TLR4 Proteins)-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.
These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.
CCL5 but not CCL2 (show CCL2 Proteins) mainly attract bovine classical monocytes and promote their differentiation into LPS (show IRF6 Proteins)-hypo-responsive macrophages.
decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis
In the pathogenesis of allergic rhinitis, substance P (show TAC1 Proteins) induces expression of RANTES in nasal mucosa.
CCL3 (show CCL3 Proteins), CCL4 (show CCL4 Proteins) and CCL5 gene expression was evaluated in response to simian-human immunodeficiency virus (SHIV) infection in a rhesus macaque model.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
chemokine (C-C motif) ligand 5
, small inducible cytokine A5
, C-C motif chemokine 5
, T-cell-specific protein RANTES
, regulated upon activation normal T-cell expressed and secreted
, small-inducible cytokine A5
, T-cell specific protein p288
, beta-chemokine RANTES
, eosinophil chemotactic cytokine
, regulated upon activation, normally T-expressed, and presumably secreted
, small inducible cytokine subfamily A (Cys-Cys), member 5
, chemokine ah294
, small inducible cytokine A5 RANTES
, chemokine CCL5/RANTES
, chemokine ligand 5