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Mouse (Murine) CSF3 Protein expressed in Escherichia coli (E. coli) - ABIN809713
Nasirikenari, Veillon, Collins, Azadi, Lau: Remodeling of marrow hematopoietic stem and progenitor cells by non-self ST6Gal-1 sialyltransferase. in The Journal of biological chemistry 2014
Human CSF3 Protein expressed in Escherichia coli (E. coli) - ABIN987880
Xie, Gorodetsky, Micewicz, Micevicz, Mackenzie, Gaberman, Levdansky, McBride: Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. in The Journal of investigative dermatology 2013
data provide novel information about the regulation of neutrophil migration in zebrafish, positioning Gcsf-Chr19 as a key signal during the course of an inflammatory process triggered by severe damage
Data indicate that Gcsf is required for the specification and proliferation of hematopoietic stem cells, suggesting that Gcsf represents an ancestral cytokine responsible for the broad support of hematopoietic stem and progenitor cells (HSPCs).
The opposing roles of G-CSF and IFNgamma in regulation of innate inflammatory responses in a murine viral encephalitis model reveal G-CSF as a potential therapeutic target.
We propose that in aggressive pancreatic ductal adenocarcinoma , elevated G-CSF contributes to tumor progression through promoting increases in infiltration of neutrophil-like cells with high immunosuppressive activity. Such a mechanism provides an avenue for a neoadjuvant therapeutic approach for this devastating disease
these data provide strong evidence for a role for G-CSF in the development of ACI after burn injury through suppression of EPO (show EPO Proteins) signaling in bone marrow erythroid cells.
physiologically produced G-CSF not only acts as a neutrophil mobilizer at the relatively late stage of acute inflammation, but also prevents exaggerated neutrophil mobilization.
data demonstrate that G-CSF is a pivotal driver of the disease progression in the K/BxN serum-transfer arthritis (STA (show SULT2A1 Proteins)) model and possibly acts in part by regulating neutrophil numbers in the circulation
SB203580 increases G-CSF expression in macrophages by increasing the stability of G-CSF mRNA via its 3'UTR, and the effect was not due to its inhibition of p38 MAPK (show MAPK14 Proteins) activity.
Results suggested that G-CSF plays an important role in preventing colitis, likely through populating immune regulatory macrophages in the intestine.
findings provide convincing evidence that monophosphoryl lipid A-induced G-CSF facilitates early expansion, mobilization, and recruitment of neutrophils to the site of infection after burn injury
Overexpression of VEGF (show VEGFA Proteins) may compensate for the G-CSF deficit through preservation of cellular components, including blood vessels, in the postinfarction heart.
G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy.
we described the construction and characterization of three G-CSF dimeric proteins generated using different linker peptides. GCSF-Lalpha had the best performance in terms of purity and in vitro activity
this study shows that cortisol inhibits CSF3 via DNA methylation (show HELLS Proteins) and inhibits invasion in first-trimester trophoblast cells
conclusion, there was an elevated lipolysis condition within the FF of Polycystic Ovary Syndrome (PCOS) with metabolic syndrome (MS) patients and the TNF-alpha (show TNF Proteins) and G-CSF levels in FF were associated with top-quality embryo percentage.
Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF (show GUCY2F Proteins) IL-8 (show IL8 Proteins), G-CSF, as well as serum IL-8 (show IL8 Proteins), MCP-1 (show CCL2 Proteins) and GM-CSF (show CSF2 Proteins) may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use.
a set of IL-17A (show IL17A Proteins)-regulated genes in keratinocytes, which recapitulate typical psoriasis genes exemplified by DEFB4A (show DEFB4 Proteins), S100A7 (show S100A7 Proteins), IL19 (show IL19 Proteins) and CSF3, based on the differences in the expression profiles of cells stimulated with six cytokines versus cells stimulated with only five cytokines lacking IL-17A (show IL17A Proteins).
The results showed that the addition of recombinant IL-1 (show IL1A Proteins) markedly increased G-CSF expression in fibroblasts; however, IL-1 (show IL1A Proteins) receptor antagonist only partially abrogated KCM-stimulated G-CSF expression, indicating the role of additional keratinocyte-releasable factors
Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF and/or GM-CSF (show CSF2 Proteins) (G(M)-CSF (show CSF1 Proteins)) synthesized by the brain. Glioblastoma cells themselves also synthesize G(M)-CSF (show CSF1 Proteins). G(M)-CSF (show CSF1 Proteins) synthesized by brain due to damage by a growing tumor and by the tumor itself stimulates bone marrow to shift hematopoiesis toward granulocytic lineages away from lymphocytic lineages.
CD146/MCAM (show MCAM Proteins) is the functional galectin-3 (show LGALS3 Proteins)-binding ligand on endothelial cell surfaces responsible for galectin-3 (show LGALS3 Proteins)-induced secretion of metastasis-promoting cytokines.
These results suggest that G-CSF could decrease the Th1 (show TH1L Proteins)/Th2 ratio in the context of immune thrombocytopenic purpura, and elucidate the direct and indirect immunomodulatory mechanisms underlying G-CSF functions in Th1 (show TH1L Proteins)/Th2 cells.
Data suggest granulocyte-colony stimulating factor (G-CSF) as a possible candidate for agents in which neutrophils can provide protection.
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene.
colony stimulating factor 3 (granulocyte)
, granulocyte colony-stimulating factor
, granulocyte colony stimulating factor
, Granulocyte colony-stimulating factor