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CX3CR1 major allele carriers V249 and T280 are significantly associated with an increased total arterial blood volume of the whole brain, especially around the bilateral precuneus, left posterior cingulate cortex, and left posterior parietal cortex.
investigated the association of CX3CR1 839C/T, CX3CR1 745G/A, polymorphisms with Age-Related Macular Degeneration (AMD (show AMD1 Proteins)) risk. These associated with an increased AMD (show AMD1 Proteins) risk (CX3CR1 839C/T, additive model: aOR=2.682, 95% CI=1.119-5.709, P=0.022, recessive model: aOR=2.729, 95% CI=1.141-6.048, P=0.010; CX3CR1 745G/A, additive model: aOR=2.614, 95% CI=1.231-6.012, P=0.020, recessive model: aOR=2.340, 95% CI=1.227-5.993, P=0.011
CX3CR1 regulated chondrocyte proliferation.
We detected a statistically significant association between the variant Ala55Thr in CX3CR1 with schizophrenia and autism spectrum disorder phenotypes
This study shown that CX3CR1 expression in both Microglia and Astrocytes in hippocampus in affected by stroke, Alzheimer's disease, and Lewy body dementia.
The US28 gene product has maintained the function of the ancestral gene and has the ability to bind and signal in response to human CX3CL1 (show CX3CL1 Proteins), the natural ligand for CX3CR1.
Our findings demonstrate that motility, invasion, and contact-independent growth of PDAC cells all increase following CX3CL1 (show CX3CL1 Proteins) exposure, and that antagonism of CX3CR1 by the inhibitor JMS (show ATRX Proteins)-17-2 reduces each of these phenotypes and correlates with a downregulation of AKT (show AKT1 Proteins) phosphorylation.
in Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses
CX3CL1 (show CX3CL1 Proteins)/CX3CR1 axis plays a key role in the development of ischemia-induced oligodendrocyte injury via p38MAPK (show MAPK14 Proteins) signaling pathway.
Soluble FKN that was efficiently shed from the surface of LPS (show IRF6 Proteins)-activated ECs in response to binding of CD16 (show CD16 Proteins)(+) monocytes to ECs, diminished monocyte adhesion in down-regulating CX3CR1 expression on the surface of CD16 (show CD16 Proteins)(+) monocytes resulting in decreased TNF (show TNF Proteins)-secretion.
Using the Theiler's virus model of encephalitis in C57BL/6 mice study shows that CCR2 (show CCR2 Proteins) as well as CX3CR1 plays a key role in the accumulation of myeloid cells in the CNS and activation of hippocampal myeloid cells upon infection.
Ang II (show AGT Proteins) up-regulates CX3CR1 expression in VSMCs via NADPH oxidase (show NOX1 Proteins)/ROS (show ROS1 Proteins)/p38 MAPK (show MAPK14 Proteins) pathway and the CX3CL1 (show CX3CL1 Proteins)/CX3CR1 axis contributes to the proliferative and pro-inflammatory effects of Ang II (show AGT Proteins) in VSMCs.
CX3CR1 ablation enhanced the neurotrophic action of microglia in Mecp2KO mice
These findings indicate that emotional and cognitive stress resilience involves CX3CR1-dependent basal and stress-induced alterations in hippocampal transcription
The effect of CX3CR1 deletion on murine acetabular development provides suggestive evidence of a susceptibility inducing role of the CX3CR1 gene on developmental dysplasia of the hip.
In Cx3cr1(-/-) mice, adult-born-granule-cells exhibited reduced spine density, dynamics and size, concomitantly with reduced contacts between Cx3cr1-deficient microglia and adult-born-granule-cells' dendritic shafts, along with increased proportion of microglia-contacted spines.
reveal CX3CR1 as a novel target for the clearance of extracellular Tau
These findings suggest that fractalkine receptor is not a universal regulator of synaptic plasticity, but rather has heterogeneous roles in specific brain regions and life stages.
Although CCR2 (show CCR2 Proteins) and CX3CR1 may synergistically impact inflammatory phenotypes, their joint deficiency did not influence the metabolic effects of a 45% high-fat diet-induced obesity in these model conditions.
that CX3CL1 (show CX3CL1 Proteins)-CX3CR1 signaling is a molecular mechanism capable of modulating microglial-mediated degeneration
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
, CX3C chemokine receptor 1
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, CX3C chemokine receptor 1-like
, Fractalkine receptor
, chemokine receptor 1
, chemokine (C-X3-C motif) receptor 1