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The studies revealed that, although overall structural and oligomerization features of CXCL3 and CXCL2 (show CXCL2 Proteins) are similar, prominent differences were observed in their surface characteristics, thus implicating a functional divergence.
Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression.
Our findings suggest that CXCL3 and its receptor CXCR2 (show CXCR2 Proteins) are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis.
results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy
CXCL3 displays antimicrobial activity against E. coli and S. aureus.
our results demonstrate the diverse mechanisms by which CXCL2 (show CXCL2 Proteins) and CXCL3 mediate normal and asthmatic airway smooth muscle cell migration
secreted growth-regulated oncogene (show RAB1A Proteins) chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells.
Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine (show CCL1 Proteins) and its receptor, CXCR2 (show CXCR2 Proteins) on the surface in T cells.
This study demonistrated that CXCL1 (show CXCL1 Proteins), CXCL2 (show CXCL2 Proteins), CXCL3, CXCL8 (show IL8 Proteins), and CXCL11 (show CXCL11 Proteins), absent from normal muscle fibers, were induced in DMD (show DMD Proteins) myofibers.
A significantly increased expression of GRO-2 (show CXCL2 Proteins), GRO-3, and IL-8 (show IL8 Proteins) in colon carcinoma as compared to normal tissue, is reported.
CXCL3/GRO-gamma is the major chemotactic factor for neutrophils in bovine milk in the absence of inflammation, and that it is secreted constitutively in milk by mammary epithelial cells.
these results have indicated that CXCL3 is a novel adipokine that facilitates adipogenesis in an autocrine and/or a paracrine manner through induction of c/ebpb (show CEBPB Proteins) and c/ebpd (show CEBPD Proteins).
Tis21 (show BTG2 Proteins) induces migration of cerebellar granule neuron precursor cells through Cxcl3, which may represent a novel target for medulloblastoma therapy
DCIP (show SAMHD1 Proteins)-1 interacts with chemokine (show CCL1 Proteins) CXCR2 (show CXCR2 Proteins) and mediates human neutrophil chemotaxis, consistent with its role during the early proinflammatory phase of dendritic cell maturation.
acts as a chemoattractant for neutrophils\; involved in the inflammatory response
chemokine (C-X-C motif) ligand 3
, C-X-C motif chemokine 3
, chemokine CXCL3/GRO-GAMMA
, GRO3 oncogene
, MGSA gamma
, growth-regulated protein gamma
, macrophage inflammatory protein 2-beta
, melanoma growth stimulatory activity gamma
, epithelial cell inflammatory protein
, cytokine-induced neutrophil chemoattractant 2
, cytokine-induced neutrophil chemoattractant-2
, macrophage inflammatory protein 2-alpha/beta
, dendritic cell inflammatory protein 1